Arthur Wallace

6476037, Nov 5, 2002

Mar 23, 2000

09/644982

Arthur W. Wallace - San Rafael CA

The Regents of the University of California - Oakland CA

A01N 4354

514258, 514262, 514253, 514565

This invention pertains to the discovery that L-arginine and type V phosphodiesterases act synergistically to inhibit vasospasm and/or to induce vasodilation. Methods are provided using combinations of L-arginine and type V phosphodiesterase inhibitors in the treatment of cardiac pathologies and/or the treatment of erectile dysfunction.

6496732, Dec 17, 2002

May 25, 2000

09/578374

Arthur Wallace - San Rafael CA

The Regents of the University of California - Oakland CA

A61N 136

607 24, 607 9, 600513, 600508

Determining the cardiac output of a patient uses first and second electrodes disposed with the peri-aortic adventitia or fat pad of the patient. Third electrode is disposed on the cardiac atrial area of the patient. Fourth electrode is placed either externally on the body surface or internally superior to electrodes one and two. A bioelectrical impedance recorder is coupled to the third and fourth electrodes to pass a current between the electrodes. A bioimpedance recorder is coupled to the first and second electrodes to measure the resulting voltage. The output of the bioelectrical impedance recorder is processed to compute a metric corresponding to the patients cardiac output. The third electrodes are adapted to be the cardiac pacing electrodes.

7677734, Mar 16, 2010

Apr 8, 2005

11/101728

Arthur Wallace - San Rafael CA, US

G03B 31/00
G02B 27/14
G09G 5/00

353 18, 359630, 345 8, 348115

Systems and methods provide audio-visual distraction to a patient while the patient is undergoing a surgical or other such medical procedure. When used in the context of a surgical procedure, local anesthetics are used to eliminate the pain of the procedure, autonomic blockade (beta blockers and/or alpha-2 agonists) is used to control autonomic responses, and audio-visual distraction is provided to distract the patient. The system allows reduction in the need for pharmacologic sedation.

20030166661, Sep 4, 2003

Sep 23, 2002

10/253404

Arthur Wallace - San Rafael CA, US

The Regents of the University of California

A61K031/5377
A61K031/519
A61K031/517

514/252160, 514/248000, 514/262100, 514/263100, 514/234500, 514/266220, 514/267000

This invention pertains to the discovery that L-arginine and type V phosphodiesterases act synergistically to inhibit vasospasm and/or to induce vasodilation. Methods are provided using combinations of L-arginine and type V phosphodiesterase inhibitors in the treatment of cardiac pathologies and/or the treatment of erectile dysfunction.

60959878, Aug 1, 2000

Sep 19, 1997

8/934036

Ascher Shmulewitz - Tel Aviv, IL
Arthur A. Wallace - San Rafael CA

Imagyn Medical Techonologies California, Inc. - Newport Beach CA

A61B 505

600547

Apparatus and methods are provided for monitoring cardiac output using bioelectrical impedance techniques in which first and second electrodes are placed in the trachea and/or bronchus in the vicinity of the ascending aorta, while an excitation current is injected into the thorax via first and second current electrodes, so that bioelectrical impedance measurements based on the voltage drop sensed by the first and second electrodes reflect voltage changes induced primarily by blood flow dynamics, rather than respiratory or non-cardiac related physiological effects. Additional sense electrodes may be provided, either internally, or externally, for which bioelectrical impedance values may be obtained. Methods are provided for computing cardiac output from bioelectrical impedance values. Apparatus and methods are also provided so that the measured cardiac output may be used to control administration of intravenous fluids to an organism or to optimize a heart rate controlled by a pacemaker.

62926896, Sep 18, 2001

Dec 8, 1999

9/458186

Arthur W. Wallace - San Rafael CA
Ascher Shmulewitz - Tel Aviv, IL

Imagyn Medical Technologies California, Inc. - Irvine CA

A61B 505

600547

Apparatus and methods are provided for monitoring cardiac output using bioelectrical impedance techniques in which three orthogonal pairs of sense electrodes are placed in the trachea or esophagus in the vicinity of the aorta, while an excitation current is injected into the intervening tissue mass via a current electrode, so that bioelectrical impedance measurements based on the voltage drop sensed by the sense electrodes reflect voltage changes induced primarily by blood flow dynamics. Methods are provided for computing cardiac output from bioelectrical impedance values using a multi-parameter algorithm derived using stepwise multiple linear regression or other optimization techniques. Apparatus and methods are also provided so that the measured cardiac output may be used to control administration of intravenous fluids or medication to an organism or to optimize a heart rate controlled by a pacemaker.