Inventors:
Jing Wu - San Mateo CA
Jay S. Tung - Belmont CA
Eugene D. Thorsett - Moss Beach CA
Michael A. Pleiss - Sunnyvale CA
Jeffrey S. Nissen - Indianapolis IN
R. Jeffrey Neitz - San Francisco CA
Lee H. Latimer - Oakland CA
Varghese John - San Francisco CA
Stephen Freedman - Walnut Creek CA
Thomas C. Britton - Carmel IN
James A. Audia - Indianapolis IN
Jon K. Reel - Carmel IN
Thomas E. Mabry - Indianapolis IN
Bruce A. Dressman - Indianapolis IN
Cynthia L. Cwi - Indianapolis IN
James J. Droste - Indianapolis IN
Steven S. Henry - New Palestine IN
Stacey L. McDaniel - Indianapolis IN
William Leonard Scott - Indianapolis IN
Russell D. Stucky - Indianapolis IN
Warren J. Porter - Indianapolis IN
Assignee:
Athena Neurosciences, Inc. - South San Francisco CA
Eli Lilly Company - Indianapolis IN
International Classification:
A61K 3155
US Classification:
51421106, 51421107, 51421204, 51421206, 51421207, 51421208, 540488, 540521, 540522, 540523, 540524, 540527
Abstract:
Disclosed are compounds which inhibit -amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimers disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits -amyloid peptide release and/or its synthesis as well as methods for treating Alzheimers disease both prophylactically and therapeutically with such pharmaceutical compositions.