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Ruiwu Liu

from Sacramento, CA
Age ~56

Ruiwu Liu Phones & Addresses

  • 3974 Woodpointe Cir, Sacramento, CA 95821
  • 3239 Beretania Way, Sacramento, CA 95834 (916) 419-9758
  • 1416 Brewerton Dr, Sacramento, CA 95833
  • 1416 Brewerton Dr APT 306, Sacramento, CA 95833 (916) 924-0861

Work

Position: Administrative Support Occupations, Including Clerical Occupations

Education

Degree: Associate degree or higher

Publications

Us Patents

Aβ-Binding Small Molecules

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US Patent:
8168800, May 1, 2012
Filed:
Oct 31, 2008
Appl. No.:
12/740329
Inventors:
Kit S. Lam - Davis CA, US
Ruiwu Liu - Sacramento CA, US
Hyun-Seok Hong - Davis CA, US
Izumi Maezawa - Davis CA, US
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
C07D 491/052
US Classification:
5483021
Abstract:
In one aspect, the present invention provides for compounds and labeled compounds of Formula I, and pharmaceutical compositions thereof. In another aspect, the present invention provides for methods of using compounds or labeled compounds of Formula I for various therapeutic and imaging purposes, including, but not limited to, treating Alzheimer's disease in patient and imaging Aβ peptide aggregates in a patient.

Heterocyclic Ligands For Integrin Imaging And Therapy

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US Patent:
8486370, Jul 16, 2013
Filed:
Sep 7, 2007
Appl. No.:
12/440219
Inventors:
Richard D. Carpenter - Suisun City CA, US
Mirela Andrei - Ploiesti, RO
Ruiwu Liu - Sacramento CA, US
Kit S. Lam - Davis CA, US
Mark J. Kurth - Davis CA, US
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
A61K 51/00
US Classification:
424 169
Abstract:
The present invention provides αβintegrin ligands that display high binding affinity, specificity, and stability. The ligands comprise a peptide having n independently selected amino acids, wherein at least one amino acid is an unnatural amino acid or a D-amino acid, and wherein n is an integer of from 3 to 20. Methods are provided for administering the ligands for treating cancer, inflammatory diseases, and autoimmune diseases. Also provided are methods for administering the ligands for imaging a tumor, organ, or tissue in a subject.

Alpha-4 Beta-1 Integrin Ligands For Imaging And Therapy

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US Patent:
20060019900, Jan 26, 2006
Filed:
May 26, 2005
Appl. No.:
11/140548
Inventors:
Kit Lam - Davis CA, US
Ruiwu Liu - Sacramento CA, US
Li Peng - Davis CA, US
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
C07K 7/08
C07K 7/06
C07K 5/06
A61K 38/10
A61K 38/08
US Classification:
514013000, 514014000, 514015000, 514016000, 514017000, 514018000, 530326000, 530327000, 530328000, 530329000, 530330000, 530331000
Abstract:
The present invention provides αβintegrin ligands that display high binding affinity, specificity, and stability. The ligands comprise a peptide having n independently selected amino acids, wherein at least one amino acid is an unnatural amino acid or a D-amino acid, and wherein n is an integer of from 3 to 20. Methods are provided for administering the ligands for treating cancer, inflammatory diseases, and autoimmune diseases. Also provided are methods for administering the ligands for imaging a tumor, organ, or tissue in a subject.

Chemical Antibodies For Immunotherapy And Imaging

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US Patent:
20100021379, Jan 28, 2010
Filed:
Jun 28, 2007
Appl. No.:
12/306244
Inventors:
Kit S. Lam - Davis CA, US
Pappanaicken R. Kumaresan - Sacramento CA, US
Amanda Enstrom - Sacramento CA, US
Ruiwu Liu - Sacramento CA, US
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
A61K 51/00
A61K 49/00
A61K 39/395
C12Q 1/02
C12N 9/96
C07K 16/00
US Classification:
424 149, 424 91, 424 96, 4241781, 435 29, 435188, 5303911, 5303913, 5303915, 5303917, 5303919
Abstract:
The present invention provides antibody conjugates comprising a targeting agent covalently attached to an antibody or fragment thereof. The antibody conjugates of the present invention are particularly useful for imaging a tumor, organ, or tissue and for treating diseases and disorders such as cancer, inflammatory diseases, autoimmune diseases, infectious diseases, and neurological disorders. Kits containing the antibody conjugates described herein find utility in a wide range of applications including, for example, in vivo imaging and immunotherapy.

Inhibitors Of Cyclin Kinase Inhibitor P21

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US Patent:
20110301192, Dec 8, 2011
Filed:
Sep 29, 2009
Appl. No.:
13/119152
Inventors:
Robert Weiss - Vacaville CA, US
Kit S. Lam - Davis CA, US
Ruiwu Liu - Sacramento CA, US
Assignee:
The regents of the University of California - Oakland CA
International Classification:
A61K 31/454
C07D 235/18
C07D 403/06
A61P 35/00
C07D 401/04
A61K 31/4184
A61K 31/4375
C07D 401/06
C07D 455/02
US Classification:
514306, 546199, 5483097, 5483061, 546138, 514322, 514394
Abstract:
The present invention provides compounds that inhibit cyclin kinase inhibitor p21, such as compounds of formula I. The present invention also provides compositions including compounds of Formula I and a pharmaceutically acceptable excipient. In addition, the present invention provides methods of inhibiting cyclin kinase inhibitor p21 and of treating cancer.

Compositions Comprising Hdac Inhibitors And Retinoids

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US Patent:
20220241227, Aug 4, 2022
Filed:
Nov 9, 2021
Appl. No.:
17/522405
Inventors:
- Oakland CA, US
Kit S. Lam - Davis CA, US
Ruiwu Liu - Davis CA, US
Assignee:
The Regents of The University of California - Oakland CA
International Classification:
A61K 31/19
A61K 47/58
A61K 31/203
A61K 31/167
A61K 31/192
A61K 31/351
A61K 31/4436
A61P 35/00
Abstract:
The present invention provides compositions and methods comprising conjugates with a polymeric backbone, e.g., polyvinyl alcohol (PVA), covalently linked histone deacetylase (HDAC) inhibitors, such as butyrate or propionate, and covalently linked retinoids, such as all-trans retinoic acid (RA). The methods and compositions of the invention are useful for the treatment or prevention of cancer or metabolic diseases in tissues such as the colon or liver.

Nitroxide Containing Amyloid Binding Agents For Imaging And Therapeutic Uses

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US Patent:
20220202962, Jun 30, 2022
Filed:
Jul 30, 2021
Appl. No.:
17/389674
Inventors:
- Oakland CA, US
Ruiwu LIU - Sacramento CA, US
International Classification:
A61K 49/20
A61K 31/4709
A61K 31/4015
C07D 207/20
A61K 31/4178
C07D 491/052
C07D 207/273
C07D 207/14
A61K 31/015
A61K 31/05
A61K 31/353
A61K 31/4184
A61K 31/423
A61K 31/428
A61K 31/4439
A61K 31/53
Abstract:
The present invention provides methods of using nitroxide spin-labeled amyloid beta-binding compounds to image amyloid. The present invention also provides nitroxide spin-labeled amyloid beta-binding compounds.

Treating Inflammation Using Llp2A-Bisphosphonate Conjugates And Mesenchymal Stem Cells

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US Patent:
20210401993, Dec 30, 2021
Filed:
Jan 5, 2021
Appl. No.:
17/142026
Inventors:
- Oakland CA, US
Ruiwu Liu - Sacramento CA, US
Wei Yao - El Dorado Hills CA, US
Kit S. Lam - Davis CA, US
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
A61K 47/54
A61K 9/00
A61K 31/663
A61K 35/28
A61K 9/08
A61K 47/64
Abstract:
The present invention provides methods of treating a subject having a primary inflammatory disease or disorder comprising administering to the subject a composition comprising a conjugate of an LLP2A peptidomimetic ligand and a bisphosphonate drug, wherein the composition comprising the LLP2A-bisphosphonate conjugate enhances the delivery of mesenchymal stem cells to a site of inflammation. Methods of enhancing an anti-inflammatory or immunomodulatory property of mesenchymal stem cells, comprising administering to a subject in need thereof the mesenchymal stem cells and a composition comprising a conjugate of an LLP2A peptidomimetic ligand and a bisphosphonate drug, are also provided.
Ruiwu Liu from Sacramento, CA, age ~56 Get Report