US Patent:
20050137223, Jun 23, 2005
Inventors:
Jian-Qiang Fan - Demarest NJ, US
Xiaoxiang Zhu - North Brunswick NJ, US
Kamlesh Sheth - North Brunswick NJ, US
International Classification:
C07D471/02
A61K048/00
A61K031/4745
US Classification:
514303000, 546118000, 564123000, 514044000
Abstract:
The present invention provides glucoimidazole (GIZ) and polyhydroxycyclohexenyl amine (PHCA) derivatives, methods of making them, and methods of use where the GIZ and PHCA derivatives have a short, flexible linker emanating from the corresponding position of the ring oxygen in a pyranose; and a lipophilic moiety connected to the linker and pharmaceutically acceptable salts thereof. More particularly, the present invention further provides a method for treating individuals having Gaucher disease by administering the novel GIZ or PHCA derivatives as “active-site specific chaperones” for the mutant glucocerebrosidase associated with the disease.