US Patent:
20100048671, Feb 25, 2010
Inventors:
Yun Qiu - Ellicott City MD, US
Kexin Xu - Baltimore MD, US
Yingqiu Xie - Timonium MD, US
International Classification:
A61K 31/7105
C07H 21/02
C12N 15/11
US Classification:
514 44 A, 536 245, 435463
Abstract:
The present invention relates to a newly discovered 44 kD isoform of Pim-1 kinase made in human cells, and to the gene and messenger RNA for the 44 kilodalton isoform. The invention further describes methods and compounds for treating, especially prostate and hematopoietic cancer, by inhibiting expression of the 44 kD isoform of Pim-1 kinase, or its ability to phosphorylate Etk kinase and breast cancer resistance protein (BCRP).