US Patent:
20200360284, Nov 19, 2020
Inventors:
- Woodcliff Lake NJ, US
Steven L. KRILL - Midland Park NJ, US
Rama Abu SHMEIS - Branchburg NJ, US
Adrian HEPNER - Ramsey NJ, US
Charles WESCOTT - Woodcliff Lake NJ, US
Tara JASKOWSKI - Woodcliff Lake NJ, US
Michael JOYCE - Woodcliff Lake NJ, US
International Classification:
A61K 9/10
A61K 31/566
A61K 47/32
A61K 47/26
A61K 9/00
A61K 31/519
A61K 47/24
Abstract:
The present disclosure provides methods of treating breast cancer including administering aqueous suspensions comprising solubilized fulvestrant, non-solubilized fulvestrant particles having one or more of an LD Dv(10) between about 1.5 and about 2.1 microns, an LD Dv(50) between about 5.5 and about 9.0 microns, and an LD Dv(90) between about 15 and about 35 microns, with the aqueous suspensions further including a surfactant, a polyvinylpyrrolidone, and a sugar alcohol, and a water-soluble excipient. The water-soluble excipient can be an aryl-Ci-6alk-OH, a Ci-6alkyl-OH, a buffering salt, a polysorbate, a polyalkylene glycol, a Ci-i2alkylene glycol, a phosphatidylcholine, or a combination thereof.