Alan A Dombkowski

20030108874, Jun 12, 2003

Nov 1, 2001

10/002536

Michael Kane - Ann Arbor MI, US
Aaron Nagel - Ypsilanti MI, US
Alan Dombkowski - Canton MI, US

Genomic Solutions, Inc.

C12Q001/68
C12P019/34

435/006000, 435/091200

The invention comprises compositions and systems to identify and compare expressed genes in a given in vivo or in vitro RNA sample, as well as the relative difference in mRNA expression between two or more samples, where desired. Furthermore, the invention comprises compositions and systems to identify novel genes. The invention comprises, without limitation, one or more mRNA specific identimers for use in reverse transcription that themselves comprise an oligo-T nucleotide sequence (at the 5′ end) linked to a nucleotide sequence VNx (at the 3′ end) where the V nucleotide immediately adjacent to the oligo-T segment is not a T.

20060105362, May 18, 2006

Aug 29, 2005

11/214436

Michael Kane - Ann Arbor MI, US
Aaron Nagel - Ypsilanti MI, US
Alan Dombkowski - Canton MI, US

C12Q 1/68
C12P 19/34

435006000, 435091200

The invention comprises compositions and systems to identify and compare expressed genes in a given in vivo or in vitro RNA sample, as well as the relative difference in mRNA expression between two or more samples, where desired. Furthermore, the invention comprises compositions and systems to identify novel genes. The invention comprises, without limitation, one or more mRNA specific identimers for use in reverse transcription that themselves comprise an oligo-T nucleotide sequence (at the 5′ end) linked to a nucleotide sequence VNx (at the 3′ end) where the V nucleotide immediately adjacent to the oligo-T segment is not a T.

20080058215, Mar 6, 2008

Mar 18, 2005

10/593412

Hyesook Kim - Bloomfield Hills MI, US
Alan A. Dombkowski - Canton MI, US
Raymond F. Novak - Orchard Lake MI, US
Brian B. Haab - Jenison MI, US

DETROIT R&D, INC. - Bloomfields Hills MI

C40B 30/04
C40B 40/10
C40B 50/06

506 9, 506 18, 506 26

An antibody microarray screen including a substrate, monoclonal and polyclonal antibodies that are purified immunoglobins, wherein the antibodies are spotted on predetermined positions on the substrate, and fluids unprocessed for immunoglobulin isolation (e.g., anti-sera, ascites fluids, or hybridoma culture media), wherein the unprocessed fluids are spotted on the predetermined positions on the substrate. Production of drug-metabolizing enzyme antibody microarrays containing closely related cytochromes P450 is disclosed. Methods of manufacturing an antibody microarray, an internal control molecule for use in an antibody microarray, a method of determining optimal spotting concentrations of IgG and a method to increase a detectable signal with microarray analysis are disclosed.

20160115224, Apr 28, 2016

Dec 11, 2015

14/966371

Hyesook Kim - Bloomfield Hills MI, US
Alan Dombkowski - Canton MI, US

Detroit R&D - Bloomfield Hills MI

C07K 16/22
G01N 33/574
C07K 16/30

A method of producing form-specific anti-peptide antibodies for a wild type protein and its one amino acid mutated protein using a peptide antigen, by obtaining a protein sequence of the wild type protein and its one amino acid mutated protein, selecting a continuous amino acid sequence without any internal cysteine residues that includes the one amino acid mutated sequence and wild type sequence corresponding to the mutated site at the end of the sequence to obtain a synthetic mutation peptide and a synthetic wild type peptide, conjugating the synthetic peptides to a carrier protein, and immunizing an animal to produce antibodies. Methods of detecting cancer and methods of treating cancer.