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Alan P Kozikowski

from Chicago, IL
Age ~75
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Also known as:
Alan Paul Kozikowski, Alan R Kozikowski, Allen P Kozikowski
Phone and address:
2128 N Racine Ave, Chicago, IL 60614
Related to:
Daniel F Kozikowski, 41Patricia Haneline, 74Alicia Kozikowski, 44
Connected to:
Heather Kozikowski, 26Josoph A Kozikowski, 41Przemek KozikowskiKent S Kozimor, 66Stanley J Kozimor, 71Paul L Kozinn, 92Janette D Kozinski, 68Jeff KozinskiRobert J Kozinski, 62Blaine Koziol

Alan Kozikowski Phones & Addresses

  • 2128 N Racine Ave, Chicago, IL 60614
  • 2222 Dayton St, Chicago, IL 60614 (773) 388-0416
  • Menominee, MI
  • Wallace, MI
  • Tucson, AZ
  • 45 Cameron Ct, Princeton, NJ 08540 (609) 921-1801
  • Arlington, VA
  • Ponte Vedra Beach, FL
  • 45 Cameron Ct, Princeton, NJ 08540 (609) 760-5099

Work

Company: University of illinois at chicago Aug 2003 Position: Professor

Education

Degree: BS School / High School: University of Michigan 1966 to 1970 Specialities: chemistry

Skills

Drug Discovery • Chemistry • Organic Chemistry • Clinical Development • Biochemistry • Medicinal Chemistry • Nmr • Biotechnology • Science • Research • Life Sciences • Molecular Biology • Drug Design • Organic Synthesis • Lifesciences • Cancer • Nuclear Magnetic Resonance • Alzheimer's Disease • Cns Disorders • Neuroscience • Epigenetics

Industries

Chemicals

Resumes

Resumes

Alan Kozikowski Photo 1

Distinguished Visiting Scientist

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Location:
14604 Maple Ln, Dolton, IL 60419
Industry:
Chemicals
Work:
University of Illinois at Chicago since Aug 2003
Professor
University of Illinois at Chicago since 2003
Professor
Education:
University of Michigan 1966 - 1970
BS, chemistry
Skills:
Drug Discovery
Chemistry
Organic Chemistry
Clinical Development
Biochemistry
Medicinal Chemistry
Nmr
Biotechnology
Science
Research
Life Sciences
Molecular Biology
Drug Design
Organic Synthesis
Lifesciences
Cancer
Nuclear Magnetic Resonance
Alzheimer's Disease
Cns Disorders
Neuroscience
Epigenetics

Business Records

Name / Title
Company / Classification
Phones & Addresses
Alan P Kozikowski
Owner, Principal
Alan P Kozikowski
Noncommercial Research Organization
2128 N Racine Ave, Chicago, IL 60614
Alan P Kozikowski
Principal
International Drug Discovery Institute
Education and Research
2128 N Racine Ave, Chicago, IL 60614

Publications

Us Patents

Tropane Derivatives And Method For Their Synthesis

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US Patent:
6350758, Feb 26, 2002
Filed:
Sep 14, 1999
Appl. No.:
09/319188
Inventors:
Alan P. Kozikowski - Princeton NJ
Gian Luca Araldi - Washington DC
Assignee:
Georgetown University - Washington DC
International Classification:
A61K 3146
US Classification:
514304, 546124, 546127, 546132
Abstract:
A compound of formula (I) wherein R -R have any of the values defined in the specification are described, as well as pharmaceutical compositions comprising a compound of formula (I), and methods for preparing and using compounds of formula (I) are described.

Combination Of Huperzine And Nicotinic Compounds As A Neuroprotective Agent

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US Patent:
6369052, Apr 9, 2002
Filed:
Jul 23, 2001
Appl. No.:
09/910819
Inventors:
Kenneth J. Kellar - Bethesda MD
Alan P. Kozikowski - Princeton NJ
Assignee:
Georgetown University - Washington DC
International Classification:
A61K 3155
US Classification:
514221, 514286, 514290, 514295, 514339, 514343
Abstract:
The present invention provides compositions and methods for treating, preventing, or reversing neuronal dysfunction including cognitive decline, such as cognitive decline associated with aging and minimal cognitive impairment; severe neurodegenerative disorders, such as Alzheimers disease; and neuronal dysfunction associated with loss of motor skills, such as Parkinsons disease and amyotrophic lateral sclerosis. The compositions and methods of the invention can also treat or prevent neuronal dysfunction resulting from CNS injury, such as stroke, spinal-cord injury, and peripheral-nerve injury. The compositions of the invention comprises a huperzine compound and a nicotinic compound.

Bicyclic Metabotropic Glutamate Receptor Ligands

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US Patent:
6376532, Apr 23, 2002
Filed:
Jan 25, 2001
Appl. No.:
09/769737
Inventors:
Alan P. Kozikowski - Princeton NJ
Darryl Hugh Steensma - New York NY
Werner Tueckmantel - Washington DC
Gian Luca Araldi - Washington DC
Assignee:
Georgetown University - Washington DC
International Classification:
A61K 31382
US Classification:
514432, 549 23, 549397, 549216, 549213, 549 5, 549 4, 548252, 548254, 514382, 514456, 424 165
Abstract:
The present invention provides bicyclic metabotropic glutamate receptor ligands, as well as compositions comprising such ligands, and and methods for their use.

Synthetic Methods For Preparation Of Protected Proanthocyanidin(S)

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US Patent:
6420572, Jul 16, 2002
Filed:
Oct 9, 1998
Appl. No.:
09/169554
Inventors:
Alan P. Kozikowski - Princeton NJ
Werner Tueckmantel - Washington DC
Marc E. Lippman - Bethesda MD
Assignee:
Mars, Incorporated - McLean VA
International Classification:
C07D31160
US Classification:
549400, 549403
Abstract:
A process is disclosed for the production of polyphenol oligomers having n polyphenol monomeric units, n being an integer from 2-18. The process includes coupling of a protected polyphenol, having protected phenolic hydroxyl groups, with a C-4 functionalized polyphenol monomer. The protected polyphenol may be a protected polyphenol monomer or a protected polyphenol oligomer having 2-17 monomeric units. Advantageously, polyphenol monomeric units forming the polyphenol oligomers may be the same or different flavanoid compounds.

Monomeric And Dimeric Heterocycles, And Therapeutic Uses Thereof

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US Patent:
6440996, Aug 27, 2002
Filed:
Oct 7, 1999
Appl. No.:
09/414106
Inventors:
Alan P. Kozikowski - Princeton NJ
Gian Luca Araldi - San Diego CA
Amir P. Tamiz - Washington DC
Assignee:
Georgetown University - Washington DC
International Classification:
A61K 31445
US Classification:
514316, 514326, 514332, 546186, 546187, 546189, 546191, 546209, 546228, 548131, 549425, 549426
Abstract:
The invention provides compounds of formula (I): wherein X and X are substituted piperidine, cyclohexane, or tetrahydropyran rings, and L is a linking group between X and X ; as well a pharmaceutical composition comprising a compound of formula I; intermediates and methods useful for preparing a compound of formula I; and therapeutic methods for treating drug addiction, Parkinsons disease, depression, or a disease wherein the administration of cocaine is indicated, comprising administering a compound of formula I or a pharmaceutically acceptable salt thereof to a mammal in need of such treatment.

Analogs Of Cocaine

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US Patent:
6472422, Oct 29, 2002
Filed:
Jan 25, 2001
Appl. No.:
09/769774
Inventors:
Alan P. Kozikowski - Princeton NJ
Gian Luca Araldi - Washington DC
Assignee:
Georgetown University - Washington DC
International Classification:
A61K 3135
US Classification:
514451, 549425, 549426, 549427, 549428
Abstract:
The invention provides a compound of formula (I): wherein R , R , R , and Y have any of the meanings defined in the specification; as well a pharmaceutical composition comprising a compound of formula I; intermediates and methods useful for preparing a compound of formula I; and therapeutic methods for treating drug addiction, Parkinsons disease or depression comprising administering a compound of formula I, to a mammal in need of such treatment.

Synthesis Of 4-Arylepicatechins

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US Patent:
6476241, Nov 5, 2002
Filed:
Sep 5, 2000
Appl. No.:
09/655360
Inventors:
Alan P. Kozikowski - Princeton NJ
Assignee:
Mars Incorporated - Mclean VA
International Classification:
C07D31158
US Classification:
549399, 549406
Abstract:
Oligomeric procyanidins containing 4-linked epicatechin units are rare in nature and have hitherto not been accessible through stereoselective synthesis. Provided herein is the preparation of the prototypical dimer, epicatechin-4,8-epicatechin, by reaction of the protected 4-ketones with aryllithium reagents derived by halogen/metal exchange from the aryl bromides. Removal of the 4-hydroxyl group from the resulting tertiary benzylic alcohols is effected by tri-n-butyltin hydride and trifluoroacetic acid in a completely stereoselective manner, resulting in hydride delivery exclusively from the face.

Ligands For Metabotropic Glutamate Receptors And Inhibitors Of Naaladase

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US Patent:
6479470, Nov 12, 2002
Filed:
Apr 27, 2000
Appl. No.:
09/559978
Inventors:
Alan P. Kozikowski - Princeton NJ
Jarda T. Wroblewski - Kensington MD
Fajun Nan - Washington DC
Assignee:
Georgetown University - Washington DC
International Classification:
A61K 3166
US Classification:
514 75, 514574, 562 8, 562 10, 562 24
Abstract:
The present invention relates to novel compounds and formulations thereof which compounds are ligands, e. g. , agonists or antagonists, for a metabotropic glutamate receptor or a NAALADase enzyme or both. The present invention also relates to methods of modulating the activity of a metabotropic glutamate receptor or a NAALADase enzyme or both, e. g. , in a subject in need thereof, using a compound or formulation of the present invention. The present invention also relates to methods of treating a subject suffering from a chronic or acute disease, malady or condition due at least in part to an abnormality in the activity of an endogenous metabotropic glutamate receptor or a NAALADase enzyme or both, using a compound or formulation of the present invention.

Isbn (Books And Publications)

Neurobiology of the Nmda Receptor: From Chemistry to the Clinic

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Author

Alan Kozikowski

ISBN #

0895737698

Neurobiology of the Nmda Receptor: From Chemistry to the Clinic

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Author

Alan Kozikowski

ISBN #

3527279296

Drug Design for Neuroscience

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Author

Alan P. Kozikowski

ISBN #

0781700612

Control profile
Alan P Kozikowski from Chicago, IL, age ~75 Get Report