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Alvin Harold Schmaier

from Gates Mills, OH
Age ~75
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Also known as:
Alvin H Schmaier, Alvin Dr Schmaier, Alvin A Schmaier, Elvin H Schmaier
Phone and address:
1970 Berkshire Rd, Mayfield Village, OH 44040
(440) 423-0430
Related to:
S L SchmaierSylvia SchmaierMarissa SchmaierChaimer S LindaLinda Z Schmaier, 76Alec Schmaier, 42
Connected to:
Edward L Schmaldinst, 69James R Schmalfeldt, 52Pam S Schmaling, 70Cathy S Schmalle, 65Joseph A Schmall, 38Phyllis L Schmalstig, 74Heather D Schmaltz, 46Janet A Schmaltz, 72Elizabeth M Schmalz, 73Greg K Schmalz, 45

Alvin Schmaier Phones & Addresses

  • 1970 Berkshire Rd, Gates Mills, OH 44040 (440) 423-0430
  • 1127 Euclid Ave, Cleveland, OH 44115 (216) 583-0579
  • 3308 The Glade St, Scio Township, MI 48103 (734) 994-9594
  • Ann Arbor, MI
  • Philadelphia, PA

Work

Company: Seidman Cancer Center Address: 11100 Euclid Ave Suite 2130, Cleveland, OH 44106 Phones: (216) 844-7753

Education

School / High School: Virginia Commonwealth University / Medical College of Virginia School of Medicine 1974

Languages

English

Awards

Healthgrades Honor Roll

Ranks

Certificate: Hematology, 1980

Images

Specialities

Hematology • Medical Oncology • Oncology

Professional Records

Medicine Doctors

Alvin Schmaier Photo 1

Dr. Alvin H Schmaier, Cleveland OH - MD (Doctor of Medicine)

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Specialties:
Hematology
Medical Oncology
Oncology
Address:
Seidman Cancer Center
11100 Euclid Ave Suite 2130, Cleveland, OH 44106
(216) 844-7753 (Phone)
Certifications:
Hematology, 1980
Internal Medicine, 1977
Medical Oncology, 1981
Awards:
Healthgrades Honor Roll
Languages:
English
Hospitals:
Seidman Cancer Center
11100 Euclid Ave Suite 2130, Cleveland, OH 44106

University Hospitals Case Medical Center
11100 Euclid Avenue, Cleveland, OH 44106
Education:
Medical School
Virginia Commonwealth University / Medical College of Virginia School of Medicine
Graduated: 1974
Medical School
Temple University Hospital
Graduated: 1974
Medical School
University Of Pennsylvania
Graduated: 1974
Alvin Schmaier Photo 2

Alvin H. Schmaier

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Specialties:
Hematology/Oncology
Work:
University Hospital Medical PhysiciansSeidman Cancer Center
11100 Euclid Ave FL 1, Cleveland, OH 44106
(216) 844-7753 (phone), (216) 844-5759 (fax)
Education:
Medical School
Virginia Commonwealth University SOM
Graduated: 1974
Procedures:
Bone Marrow Biopsy
Conditions:
Anemia
Hemolytic Anemia
Iron Deficiency Anemia
Sickle-Cell Disease
Acute Renal Failure
Languages:
English
Spanish
Description:
Dr. Schmaier graduated from the Virginia Commonwealth University SOM in 1974. He works in Cleveland, OH and specializes in Hematology/Oncology. Dr. Schmaier is affiliated with University Hospitals Cleveland Medical Center.
Alvin Schmaier Photo 3

Alvin Schmaier, Cleveland OH

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Specialties:
Internal Medicine
Hematology
Medical Oncology
Hematology & Oncology
Work:
UH Case Medical Center
11100 Euclid Ave, Cleveland, OH 44106
Education:
Virginia Commonwealth University (1974)

License Records

Alvin H Schmaier

License #:
MT003376T - Expired
Category:
Medicine
Type:
Graduate Medical Trainee

Resumes

Resumes

Alvin Schmaier Photo 4

Robert W Kellermeyer Professor Of Oncology

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Location:
Cleveland, OH
Industry:
Higher Education
Work:
University of Michigan Aug 1991 - Nov 2005
Professor
Case Western Reserve University Aug 1991 - Nov 2005
Robert W Kellermeyer Professor of Oncology
Temple University 1980 - 1991
Assistant Professor To Full Professor
Education:
Temple University - Lewis Katz School of Medicine 1979 - 1980
Hospital of the University of Pennsylvania 1977 - 1979
Temple University Hospital 1974 - 1977
Medical College of Virginia 1970 - 1974
Doctor of Medicine, Doctorates, Medicine University of Virginia 1966 - 1970
Bachelors, Bachelor of Arts, Philosophy
Skills:
Life Sciences
Molecular Biology
Cell Biology
Biochemistry
Cell Culture
Western Blotting
Clinical Research
Protein Chemistry
Science
Research
Hemostasis and Thrombosis
Clinical Hematology
Alvin Schmaier Photo 5

Owner

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Location:
Cleveland, OH
Industry:
Biotechnology
Work:
Thromgen
Owner
Case Western Reserve University
Robert W Kellermeyer Professor of Hematology and Oncology University Hospitals Cleveland Medical Center
Education:
University of Virginia 1966 - 1970

Business Records

Name / Title
Company / Classification
Phones & Addresses
Alvin Harold Schmaier
Medical Doctor
University Hospital Case Medical Center
General Hospital
1100 Euclid Ave, Cleveland, OH 44106
Alvin Harold Schmaier
Alvin Schmaier MD
Internist
11100 Euclid Ave, Cleveland, OH 44106
(216) 368-1172
Alvin H Schmaier
ALVIN H. SCHMAIER LLC
Alvin Schmaier
President
Thromgen Inc
Commercial Physical Research
803 N Main St, Ann Arbor, MI 48104
(734) 930-9741

Publications

Isbn (Books And Publications)

Hematology for Medical Students

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Author

Alvin H. Schmaier

ISBN #

0781731208

Us Patents

Peptide Analogs As Selective Inhibitors Of Thrombin Activation Of Protease Activated Receptor 1

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US Patent:
6544750, Apr 8, 2003
Filed:
Aug 17, 1999
Appl. No.:
09/375808
Inventors:
Alvin H. Schmaier - Ann Arbor MI
Ahmed A. K. Hasan - Dexter MI
Assignee:
Thromgen, Inc. - Ann Arbor MI
Regents of the University of Michigan - Ann Arbor MI
International Classification:
G01N 3353
US Classification:
435 71, 530350, 530300, 514 12
Abstract:
The invention relates to inhibiting human platelet aggregation, thrombosis and cell activation mediated by PAR1 with peptide analogs corresponding to those of Formula I and II, wherein Formula I is: wherein: Z is any naturally occurring amino acid, excluding cysteine; and wherein Formula II is: wherein: Z is any naturally occurring amino acid, excluding cysteine.

Bradykinin Analogs As Selective Inhibitors Of Cell Activation

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US Patent:
6982249, Jan 3, 2006
Filed:
Apr 21, 1998
Appl. No.:
09/402732
Inventors:
Alvin H. Schmaier - Ann Arbor MI, US
Ahmed A. K. Hasan - Dexter MI, US
Assignee:
The Regents of the University of Michigan - Ann Arbor MI
International Classification:
C07K 5/09
C07K 7/00
US Classification:
514 12, 514 13, 514 14, 514 15, 514 16, 514 17, 514 18, 530324, 530325, 530326, 530327, 530328, 530329
Abstract:
The present invention provides bradykinin peptide analogs, compositions, and methods of inhibiting thrombin-induced platelet and other cell activation. The bradykinin analogs comprise single or multiple peptide segments. The invention also provides a method for identifying compounds that selectively inhibit thrombin-induced platelet and other cell activation.

Synthetic Peptide Analogs Of Arg-Pro-Pro-Gly-Phe As Selective Inhibitors Of Thrombin And Thrombin Activation Of Protease Activated Receptors 1 And 4

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US Patent:
7074765, Jul 11, 2006
Filed:
May 1, 2003
Appl. No.:
10/426968
Inventors:
Alvin H. Schmaier - Ann Arbor MI, US
Ahmed A. K. Hasan - Ann Arbor MI, US
Assignee:
The Regents of the University of Michigan - East Lansing MI
Thromgen, Inc. - Ann Arbor MI
International Classification:
A61K 38/08
A61K 39/16
C07K 7/18
C07K 14/00
US Classification:
514 12, 514 17, 530314, 530324, 530330
Abstract:
The invention relates to compounds and methods for inhibiting human platelet aggregation, thrombosis and cell activation mediated by PAR1 and PAR4 using peptide analogs of Arg-Pro-Pro-Gly-Phe that contain one or more amino acid substitutions. The invention also includes screening methods for identifying compounds that inhibit thrombin mediated activities.

Synthetic Peptide Inhibitors Of Thrombin And Thrombin Activation Of Protease Activated Receptors 1 And 4

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US Patent:
7879792, Feb 1, 2011
Filed:
Jun 2, 2005
Appl. No.:
11/142364
Inventors:
Alvin H. Schmaier - Ann Arbor MI, US
Henry I. Mosberg - Ann Arbor MI, US
Fernanda F. Marques - Ann Arbor MI, US
John Hilfinger - Ann Arbor MI, US
Assignee:
The Regents of the University of Michigan - Ann Arbor MI
International Classification:
A61K 38/00
A61K 38/04
A61K 38/36
US Classification:
514 11, 514 17, 530330, 424 9464
Abstract:
The invention relates to synthetic peptide analogs of D-Arg-Oic-Pro-Gly-Phe and methods of their use to inhibit human platelet aggregation, thrombosis and cell activation mediated by PAR1 and PAR4.

Modulation Of Blood Pressure And Inhibition Of Platelet Activation With Kininogen Fragment

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US Patent:
54729459, Dec 5, 1995
Filed:
Feb 9, 1994
Appl. No.:
8/193114
Inventors:
Alvin H. Schmaier - Ann Arbor MI
Yongping Jiang - Northville MI
Assignee:
Temple University- of the Commonwealth System of Higher Education - Philadelphia PA
International Classification:
A61K 3817
C07K 1447
US Classification:
514 12
Abstract:
The release of bradykinin into the circulatory system is potentiated by administration of a polypeptide having an amino acid sequence corresponding to domain 3 of the human kininogen heavy chain. The polypeptide competitively inhibits the binding of high and low molecular weight kininogen to platelets and other cells which protect the kininogens from kallikrein cleavage, thereby increasing the level of bradykinin in the cirulation. The resulting in vivo effect is an intravascular elevation of bradykinin and concomitant lowering of blood pressure. The domain 3 polypeptide also inhibits thrombin-induced platelet and endothelial cell activation.

Bradykinin Analogs As Selective Thrombin Inhibitors

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US Patent:
61437190, Nov 7, 2000
Filed:
Jul 16, 1996
Appl. No.:
8/676242
Inventors:
Alvin H. Schmaier - Ann Arbor MI
Ahmed A. K. Hasan - Dexter MI
Assignee:
The Regents of the University of Michigan - Ann Arbor MI
International Classification:
A61K 3816
C07K 1400
US Classification:
514 12
Abstract:
Thrombin-induced and ADP-induced platelet and other cell activation is inhibited without affecting thrombin's other proteolytic activity by administration of a bradykinin sequence related analogous peptide. Bradykinin analogs are peptides to which substitutions, additions or deletions have been made to the first four amino acids of the amino acid sequence of native bradykinin. The bradykinin analogs described inhibit. alpha. -thrombin-induced and ADP-induced platelet activation and secretion, inhibit. alpha. -thrombin-induced calcium mobilization, and prevent. alpha. -thrombin from cleaving its platelet receptor. The bradykinin analogs may comprise single- or multiple-chain peptides.

Method For Detecting Human Kininogen Using Monoclonal Antibodies Thereto

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US Patent:
50473239, Sep 10, 1991
Filed:
Oct 30, 1989
Appl. No.:
7/429262
Inventors:
Robert W. Colman - Philadelphia PA
Alvin H. Schmaier - Philadelphia PA
Assignee:
Temple University of the Commonwealth System of Higher Education - Philadelphia PA
International Classification:
G01N 3353
G01N 33543
US Classification:
435 721
Abstract:
Two novel cell lines, ATCC #HB-8963 and ATCC #HB-8964 produce monoclonal antibody to human kininogen. One of the antibodies specifically recognizes the heavy chain of high and low molecular weight kininogen (the later protein is identical to alpha cysteine protease inhibitor). The other antibody recognizes the light chain of high molecular weight kininogen. The hybridomas are formed by fusing spleen cells from immunized BALB/c AnSkh mice with P3X63Ag8 or SP2/0-Ag14 myeloma cells. Diagnostic, therapeutic and biochemical uses of the monoclonal antibodies are provided.

Monoclonal Antibodies To Human Kininogen And Methods Of Preparing Same

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US Patent:
49084313, Mar 13, 1990
Filed:
Jan 22, 1986
Appl. No.:
6/821367
Inventors:
Robert W. Colman - Philadelphia PA
Alvin H. Schmaier - Philadelphia PA
Assignee:
Temple University-of the Commonwealth System of Higher Education - Philadelphia PA
International Classification:
C07K 1504
C12N 500
US Classification:
530387
Abstract:
Two novel cell lines, ATCC #HB-8963 and ATCC #HB-8964 produce monoclonal antibody to human kininogen. One of the antibodies specifically recognizes the heavy chain of high and low molecular weight kininogen (the later protein is identical to alpha cysteine protease inhibitor). The other antibody recognizes the light chain of high molecular weight kininogen. The hybridomas are formed by fusing spleen cells from immunized BALB/c AnSkh mice with P3X63Ag8 or SP2/0-Ag14 myeloma cells. Diagnostic, therapeutic and biochemical uses of the monoclonal antibodies are provided.
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Alvin Harold Schmaier from Gates Mills, OH, age ~75 Get Report