US Patent:
20230025608, Jan 26, 2023
Inventors:
- Charlottesville VA, US
- Birmingham, GB
Stacy Alyse Malaker - Menlo Park CA, US
Victor H. Engelhard - Crozet VA, US
Angela L. Ambakhutwala - Glen Allen VA, US
Kara L. Cummings - Charlottesville VA, US
Rebecca C. Obeng - Charlottesville VA, US
Mark Cobbold - Winchester MA, US
Assignee:
University of Virginia Patent Foundation - Charlottesville VA
The University of Birmingham - Birmingham
International Classification:
A61K 39/00
A61K 35/15
A61K 35/17
A61K 45/06
C07K 16/28
G01N 33/574
G01N 33/68
Abstract:
A set of target peptides are presented by HLA A*0101, A*0201, A*0301, B*4402, B*2705, B*1402, and B*0702 on the surface of disease cells. They are envisioned to among other things (a) stimulate an immune response to the proliferative disease, e.g., cancer, (b) to function as immunotherapeutics in adoptive T cell therapy or as a vaccine, (c) facilitate antibody recognition of tumor boundaries in surgical pathology samples, (d) act as biomarkers for early detection and/or diagnosis of the disease, and (e) act as targets in the generation antibody-like molecules which recognize the target-peptide/MHC complex.