Inventors:
Stephen Howell - Del Mar CA
Atul Khandwala - Edgewater NJ
Om P. Sachdey - New City NY
Charles G. Smith - Rancho Santa Fe CA
Assignee:
Chemex Pharmaceuticals, Inc. - Tarrytown NY
International Classification:
A61K 31045
A61K 3105
Abstract:
A method and composition for treating multidrug resistance in a mammal, in which the composition includes NDGA or an analog of NDGA in accordance with the following formula: ##STR1## wherein R. sub. 1 and R. sub. 2 are independently H, lower alkyl or lower acyl; R. sub. 3, R. sub. 4, R. sub. 5, and R. sub. 6 are independently H or lower alkyl; R. sub. 7, R. sub. 8 and R. sub. 9 are independently H, hydroxy, lower alkoxy or lower acyloxy; and R. sub. 10, R. sub. 11, R. sub. 12 and R. sub. 13 are independently H or lower alkyl, in a pharmaceutically acceptable vehicle. The method is particularly suitable for administering an antineoplastic agent, and the composition includes the combination of NDGA, or an analog with such an antineoplastic agent.