Bo N Han

7598291, Oct 6, 2009

Sep 2, 2004

10/933114

Marcel Nimni - Santa Monica CA, US
Bo Han - Temple City CA, US

A61K 31/352
A61K 31/35

514456, 514453, 424401

A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an antioxidant compound in a quantity sufficient to enhance collagen synthesis in the skin; (2) an organic penetrant in which the antioxidant compound is soluble in a sufficient quantity that a concentration of the antioxidant compound sufficient to enhance collagen synthesis can be applied topically and penetrate the skin; (3) a mixture of essential amino acids; (4) a supplemental source of sulfur; and (5) a topical pharmaceutically acceptable carrier. The antioxidant compound can be lipoic acid, a lipoic acid analogue or derivative, a bioflavonoid, a constituent of ginkgo, or an isoflavone. The organic penetrant is preferably benzyl alcohol.

20060067959, Mar 30, 2006

Sep 28, 2004

10/951824

Marcel Nimni - Santa Monica CA, US
Bo Han - Temple City CA, US
Bruce Sand - Westlake Village CA, US

A61K 8/49
A61K 31/375
A61K 31/198

424401000, 514440000, 514474000, 514561000

An improved composition for treatment of the skin comprises: (1) methionine and cysteine in a quantity sufficient to accelerate restoration of the integrity and fullness of the skin; (2) a mixture of essential amino acids in a quantity sufficient to accelerate restoration of the integrity and fullness of the skin, the mixture comprising isoleucine, leucine, lysine, phenylalanine, threonine, tryptophan, valine, histidine, and arginine; (3) at least one antioxidant in a quantity sufficient to accelerate restoration of the integrity and fullness of the skin; (4) at least one cross-linking agent in a quantity sufficient to accelerate restoration of the integrity and fullness of the skin; (5) at least one metallic catalyst in a quantity sufficient to accelerate restoration of the integrity and fullness of the skin; (6) at least one transepidermal delivery agent in a quantity sufficient to promote delivery of the composition to the skin; and (7) a topical pharmaceutically acceptable carrier. The antioxidant can be ascorbic acid. The cross-linking agent can be proanthocyanidin or silybin. The metallic catalyst can be Cu (II) in a suitable cupric salt. The transepidermal delivery agent can be benzyl alcohol.

20080241211, Oct 2, 2008

Mar 27, 2008

12/057236

Bo Han - Temple City CA, US
Marcel Nimni - Santa Monica CA, US

University of Southern California - Los Angeles CA

A61K 9/00
A61K 38/16
A61K 31/352
A61P 19/08

424423, 424484, 514 12, 514456

This invention provides a novel medical appliance for repairing, regenerating, maintaining, and/or augmenting a bone. The medical appliance generally includes an osteoinductive agent, an osteoinductive enhancer, and a carrier matrix. Also disclosed are methods, compositions, kits, and bone matrix formulations for regenerating, maintaining, and/or augmenting a bone. Exemplary preferred osteoinductive agents include growth factors such as BMP and TGF-β. Exemplary preferred osteoinductive enhancers include phytoestrogens such as naringin.

20100150892, Jun 17, 2010

Dec 16, 2009

12/639918

Bo Han - Los Angeles CA, US

UNIVERSITY OF SOUTHERN CALIFORNIA - Los Angeles CA

A61K 35/14

424 9372

Methods of repairing and regenerating hard or soft tissue and reducing inflammation, anti-angiogenesis and anti-osteogenesis in a mammal and related methods of removing PF4 from platelets containing blood preparations. In one embodiment, the method comprises administering to a mammal platelets containing blood preparation where the PF4 has been reduced from the platelet containing blood preparation to repair and regenerate hard and soft tissue in the mammal.

20100160244, Jun 24, 2010

Oct 5, 2009

12/573309

Marcel Nimni - Santa Monica CA, US
Bo Han - Temple City CA, US

A61K 31/385
A61K 31/352
A61K 31/7048
A61K 31/197

514 27, 514440, 514456, 514562

A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an antioxidant compound in a quantity sufficient to enhance collagen synthesis in the skin; (2) an organic penetrant in which the antioxidant compound is soluble in a sufficient quantity that a concentration of the antioxidant compound sufficient to enhance collagen synthesis can be applied topically and penetrate the skin; (3) a mixture of essential amino acids or hydrolyzed whey protein; (4) a supplemental source of sulfur; and (5) a topical pharmaceutically acceptable carrier. The antioxidant compound can be lipoic acid or a lipoic acid analogue or derivative. The organic penetrant is preferably benzyl alcohol. Other ingredients, such as esters of tocopherol and ascorbic acid, can be included.

20100215715, Aug 26, 2010

Feb 19, 2010

12/709238

Bo Han - Temple City CA, US
Kenrick Kuwahara - Woodland Hills CA, US

University of Southern California - Los Angeles CA

A61K 35/12
A61K 35/48
A61P 19/00

424423, 424 937

The present invention discloses methods and compositions comprising a biocompatible gel that is used in tissue repair and regeneration. Once the gel is administered to a tissue site in need of repair or regeneration, the cells migrate from the gel into the tissue and repair or regenerate the tissue.

20120010146, Jan 12, 2012

Nov 3, 2009

13/127275

Bo Han - Temple City CA, US
Marcel E. Nimni - Santa Monica CA, US

HANCOCK JAFFE LABORATORIES, INC. - Irvine CA

A61K 38/39
A61P 17/00

514 172, 514 186, 514 11, 514 2192

An injectable composition having dermal filling and tissue expanding activity comprises (1) a quantity of elastin sufficient to bring about dermal filling and tissue expansion when injected into a subject in need of dermal filling and tissue expansion, and (2) a pharmaceutically acceptable carrier. The composition can further comprise collagen, in other alternatives, the composition can further comprise hyaluronic acid, and one or more of the elastin, the collagen, and the hyaluronic acid, if present can be cross-linked, either intramolecularly or intermolecularly. The elastin, however, is the primary filler, even if collagen or hyaluronic acid are included in the composition

20130202564, Aug 8, 2013

Apr 8, 2011

13/640027

Bo Han - Temple City CA, US
Kenrick Kuwahara - Woodland Hills CA, US

UNIVERSITY OF SOUTHERN CALIFORNIA - Los Angeles CA

A61K 47/42
A61K 38/54

424 937, 424 942, 424 943, 435174, 435177

This invention provides a composition for controlled-release of polypeptide growth factors useful in tissue repair or engineering. The composition include a polypeptide growth factor covalently cross-linked to a biocompatible substrate by a transgultaminase. The cross-linking tethers the growth factor to a substrate so that it will not diffuse away from the desired site of application. It also concomitantly inactivates the growth factor. Release and reactivation of the growth factor can be achieved by endogenously produced metalloproteinase (MMPs) or exogenously provided proteases such as collagenases. Also provided are scaffolds, transplant devices, methods for using the same and methods for making the same,