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Chung-Jen Hou Phones & Addresses

  • Pensacola, FL

Publications

Us Patents

Positively Charged Membrane

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US Patent:
6780327, Aug 24, 2004
Filed:
Dec 12, 2001
Appl. No.:
09/914163
Inventors:
Xiaosong Wu - Pensacola FL
Chung-Jen Hou - Pensacola FL
Jayesh Dharia - Pensacola FL
Peter Konstantin - Heinade, DE
Yujing Yang - Pensacola FL
Assignee:
Pall Corporation - East Hills NY
International Classification:
B01D 6114
US Classification:
210660, 210488, 210490, 21050021, 21050037, 21050038, 2105021, 427245, 521 27
Abstract:
The present invention provides a positively charged microporous membrane having a protein binding capacity about 25 mg/ml or greater comprising a hydrophilic porous substrate and a crosslinked coating that provides a fixed positive charge to the membrane. The present invention further provides a positively charged microporous membrane comprising a porous substrate and a crosslinked coating comprising pendant cationic groups. The membranes of the present invention find use in a variety of applications including ion-exchange chromatography, macromolecular transfer, as well as detection, filtration and purification of biomolecules such as proteins, nucleic acids, endotoxins, and the like.

Negatively Charged Membrane

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US Patent:
6783937, Aug 31, 2004
Filed:
Dec 12, 2001
Appl. No.:
09/914165
Inventors:
Chung-Jen Hou - Pensacola FL
Peter Konstantin - Heinade, DE
Yujing Yang - Pensacola FL
Assignee:
Pall Corporation - East Hills NY
International Classification:
C12Q 168
US Classification:
435 6, 210483, 210490, 21050035, 21050038, 21050041, 264 41, 427244, 435 4, 435180, 436 86, 436 94
Abstract:
The present invention provides, in certain embodiments, a negatively charged microporous membrane comprising a porous substrate and a crosslinked coating having fixed negative charges. The crosslinked coating can be prepared, e. g. , from a polymerized composition comprising an unsaturated monomer having an anionic group, an N-(hydroxymethyl)- and/or N-(alkoxymethyl)-acrylamide, a hydrophilic unsaturated monomer, and an initiator. The present invention further provides, in some embodiments, a negatively charged microporous membrane comprising a porous substrate and a crosslinked coating prepared from a polymerized composition comprising an unsaturated monomer having an anionic group, an N-(hydroxymethyl)- or N-(alkoxymethyl)-acrylamide, a polysaccharide, and an initiator. The membranes of the present invention are suitable for use in ion exchange chromatography, for example, in the separation and purification of positively charged species such as proteins.

Positively Charged Membrane

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US Patent:
6851561, Feb 8, 2005
Filed:
Jul 15, 2004
Appl. No.:
10/891098
Inventors:
Xiaosong Wu - Pensacola FL, US
Chung-Jen Hou - Pensacola FL, US
Jayesh Dharia - Pensacola FL, US
Peter Konstantin - Boulder CO, US
Yujing Yang - Newton MA, US
Assignee:
Pall Corporation - East Hills NY
International Classification:
B01D063/14
B01D063/06
B01D069/10
B01D069/12
B01D071/56
US Classification:
210490, 210435, 210488, 2104931, 21049701, 21050021, 21050037, 21050038
Abstract:
The present invention provides a positively charged microporous membrane having a protein binding capacity of about 25 mg/ml or greater comprising a hydrophilic porous substrate and a crosslinked coating that provides a fixed positive charge to the membrane. The present invention further provides a positively charged microporous membrane comprising a porous substrate and a crosslinked coating comprising pendant cationic groups. The membranes of the present invention find use in a variety of applications including ion-exchange chromatography, macromolecular transfer, as well as detection, filtration and purification of biomolecules such as proteins, nucleic acids, endotoxins, and the like.

Filter Device And Filter Element Comprising At Least One Negatively Charged Membrane

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US Patent:
6860393, Mar 1, 2005
Filed:
Jul 21, 2004
Appl. No.:
10/895048
Inventors:
Chung-Jen Hou - Pensacola FL, US
Peter Konstantin - Boulder CO, US
Yujing Yang - Newton MA, US
Assignee:
Pall Corporation - East Hills NY
International Classification:
B01D063/14
B01D063/10
B01D067/00
B01D071/00
US Classification:
210435, 210483, 210490, 2104931, 21049701, 2104971, 21050035, 21050038, 21050041, 2105121, 264 41, 427244
Abstract:
The present invention provides, in certain embodiments, a negatively charged microporous membrane comprising a porous substrate and a crosslinked coating having fixed negative charges. The crosslinked coating can be prepared, e. g. , from a polymerized composition comprising an unsaturated monomer having an anionic group, an N-(hydroxymethyl)- and/or N-(alkoxymethyl)-acrylamide, a hydrophilic unsaturated monomer, and an initiator. The present invention further provides, in some embodiments, a negatively charged microporous membrane comprising a porous substrate and a crosslinked coating prepared from a polymerized composition comprising an unsaturated monomer having an anionic group, an N-(hydroxymethyl)- or N-(alkoxymethyl)-acrylamide, a polysaccharide, and an initiator. The membranes of the present invention are suitable for use in ion exchange chromatography, for example, in the separation and purification of positively charged species such as proteins.

Positively Charged Membrane

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US Patent:
7094347, Aug 22, 2006
Filed:
Jan 18, 2005
Appl. No.:
11/035950
Inventors:
Xiaosong Wu - Pensacola FL, US
Chung-Jen Hou - Pensacola FL, US
Jayesh Dharia - Pensacola FL, US
Peter Konstantin - Boulder CO, US
Yujing Yang - Newton MA, US
Assignee:
Pall Corporation - East Hills NY
International Classification:
B01D 63/00
B01D 63/08
B01D 39/16
B01D 29/46
B01D 63/14
US Classification:
21032184, 21032188, 21050035, 21050037, 21050038, 210488, 210490, 2104931, 21032186
Abstract:
The present invention provides a positively charged microporous membrane having a protein binding capacity of about 25 mg/ml or greater comprising a hydrophilic porous substrate and a crosslinked coating that provides a fixed positive charge to the membrane. The present invention further provides a positively charged microporous membrane comprising a porous substrate and a crosslinked coating comprising pendant cationic groups. The membranes of the present invention find use in a variety of applications including ion-exchange chromatography, macromolecular transfer, as well as detection, filtration and purification of biomolecules such as proteins, nucleic acids, endotoxins, and the like.

Negatively Charged Membrane

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US Patent:
7132049, Nov 7, 2006
Filed:
Jan 19, 2005
Appl. No.:
11/037356
Inventors:
Chung-Jen Hou - Pensacola FL, US
Peter Konstantin - Boulder CO, US
Yujing Yang - Newton MA, US
Assignee:
Pall Corporation - East Hills NY
International Classification:
B01D 39/00
B01D 63/00
B01D 11/00
C02F 1/44
US Classification:
21050035, 21032175, 21032177, 2103218, 2104931, 21050038
Abstract:
The present invention provides, in certain embodiments, a negatively charged microporous membrane comprising a porous substrate and a crosslinked coating having fixed negative charges. The crosslinked coating can be prepared, e. g. , from a polymerized composition comprising an unsaturated monomer having an anionic group, an N-(hydroxymethyl)- and/or N-(alkoxymethyl)-acrylamide, a hydrophilic unsaturated monomer, and an initiator. The present invention further provides, in some embodiments, a negatively charged microporous membrane comprising a porous substrate and a crosslinked coating prepared from a polymerized composition comprising an unsaturated monomer having an anionic group, an N-(hydroxymethyl)- or N-(alkoxymethyl)-acrylamide, a polysaccharide, and an initiator. The membranes of the present invention are suitable for use in ion exchange chromatography, for example, in the separation and purification of positively charged species such as proteins.

Positively Charged Membrane

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US Patent:
7223341, May 29, 2007
Filed:
Jul 6, 2006
Appl. No.:
11/480977
Inventors:
Xiaosong Wu - Pensacola FL, US
Chung-Jen Hou - Pensacola FL, US
Jayesh Dharia - Pensacola FL, US
Peter Konstantin - Boulder CO, US
Yujing Yang - Newton MA, US
Assignee:
Pall Corporation - East Hills NY
International Classification:
B01D 39/14
B01D 63/00
US Classification:
21050037, 21050021, 21050035, 21050038, 21050041, 210490
Abstract:
The present invention provides a positively charged microporous membrane having a protein binding capacity of about 25 mg/ml or greater comprising a hydrophilic porous substrate and a crosslinked coating that provides a fixed positive charge to the membrane. The present invention further provides a positively charged microporous membrane comprising a porous substrate and a crosslinked coating comprising pendant cationic groups. The membranes of the present invention find use in a variety of applications including ion-exchange chromatography, macromolecular transfer, as well as detection, filtration and purification of biomolecules such as proteins, nucleic acids, endotoxins, and the like.

Positively Charged Membrane

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US Patent:
7396465, Jul 8, 2008
Filed:
May 1, 2007
Appl. No.:
11/742749
Inventors:
Xiaosong Wu - Pensacola FL, US
Chung-Jen Hou - Pensacola FL, US
Jayesh Dharia - Pensacola FL, US
Peter Konstantin - Boulder CO, US
Yujing Yang - Newton MA, US
Assignee:
Pall Corporation - East Hills NY
International Classification:
B01D 71/26
B01D 71/28
B01D 71/40
B01D 71/44
B01D 71/06
US Classification:
21050021, 21050037, 21050038, 21050041
Abstract:
The present invention provides a positively charged microporous membrane having a protein binding capacity of about 25 mg/ml or greater comprising a hydrophilic porous substrate and a crosslinked coating that provides a fixed positive charge to the membrane. The present invention further provides a positively charged microporous membrane comprising a porous substrate and a crosslinked coating comprising pendant cationic groups. The membranes of the present invention find use in a variety of applications including ion-exchange chromatography, macromolecular transfer, as well as detection, filtration and purification of biomolecules such as proteins, nucleic acids, endotoxins, and the like.
Chung-Jen Hou from Pensacola, FL Get Report