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Clifford Labaw Phones & Addresses

  • 5521 Morris St, Philadelphia, PA 19144
  • 51 Orr Rd, Delta, PA 17314

Publications

Us Patents

Carvedilol Salts, Corresponding Compositions, Methods Of Delivery And/Or Treatment

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US Patent:
7750036, Jul 6, 2010
Filed:
Nov 24, 2004
Appl. No.:
10/997230
Inventors:
Christopher S. Brook - King of Prussia PA, US
Pingyun Y. Chen - Indianapolis IN, US
Wei Chen - Woodbury MN, US
Qunying Dai - King of Prussia PA, US
Philip C. Dell'Orco - King of Prussia PA, US
Clifford S. Labaw - King of Prussia PA, US
Ann Marie Diederich - King of Prussia PA, US
Choon K. Oh - Collegeville PA, US
Claire Hisler - Meyzieu, FR
David H. Igo - Research Triangle Park NC, US
Lee M. Katrincic - King of Prussia PA, US
Li-Jen Ping - King of Prussia PA, US
Paul G. Spoors - King of Prussia PA, US
Jun Wang - King of Prussia PA, US
Christopher Werner - King of Prussia PA, US
Assignee:
SB Pharmco Puerto Rico Inc. - Hato Rey PR
International Classification:
A61K 31/403
C07D 209/82
US Classification:
514411, 548440
Abstract:
The present invention relates to a salt of carvedilol and/or corresponding solvates thereof, compositions containing such carvedilol and/or corresponding solvates thereof, and/or methods of using the aforementioned compound(s) in the treatment of certain disease states in mammals, in particular man. The present invention further relates to carvedilol phosphate salts, and/or solvates thereof, which include a novel crystalline form of carvedilol dihydrogen phosphate (i. e. , which is the dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy)ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate, etc. ) and/or other corresponding solvates thereof, compositions containing these carvedilol phosphate salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc.

Method For The Synthesis Of Quinoline Derivatives

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US Patent:
20080194623, Aug 14, 2008
Filed:
Aug 2, 2006
Appl. No.:
11/997378
Inventors:
Clifford S. Labaw - Philadelphia PA, US
Peng Liu - King of Prussia PA, US
International Classification:
A61K 31/47
C07D 215/52
US Classification:
514312, 546156
Abstract:
This invention relates to novel intermediates and processes for preparing pharmaceutically active quinoline compounds, including (−)-(S)—N-(α-ethylbenzyl)-3-hydroxy-2-phenylquinoline-4-carboxamide.

Imidazolemethylphosphonium Salts

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US Patent:
41044720, Aug 1, 1978
Filed:
May 24, 1977
Appl. No.:
5/800150
Inventors:
Clifford Steven Labaw - Philadelphia PA
Robert Lee Webb - West Chester PA
George Robert Wellman - Warminster PA
Assignee:
SmithKline Corporation - Philadelphia PA
International Classification:
C07F 965
US Classification:
548337
Abstract:
New imidazolemethylphosphonium salts having a degradable group at the 2-position which are useful intermediates for preparing histamine H. sub. 2 antagonists.

Process For Preparing New Imidazolemethylphosphonium Salts

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US Patent:
41638581, Aug 7, 1979
Filed:
Mar 8, 1978
Appl. No.:
5/884658
Inventors:
Clifford S. Labaw - Philadelphia PA
Robert L. Webb - West Chester PA
George R. Wellman - Warminster PA
Assignee:
SK&F Lab Co. - Carolina PR
International Classification:
C07D23114
US Classification:
548342
Abstract:
New imidazolemethylphosphonium salts having a degradable group at the 2-position which are useful intermediates for preparing histamine H. sub. 2 antagonists. This invention concerns the preparation of imidazolemethylphosphonium salts having no substituent at the 2-position by heating the compounds referred to above.

2-(2-Halo-3,4-Dimethoxybenzyl)-5-(4-Methoxyphenyl)-Oxazolidines

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US Patent:
47821639, Nov 1, 1988
Filed:
Aug 17, 1987
Appl. No.:
7/086115
Inventors:
Clifford S. Labaw - Philadelphia PA
Alan W. Tremper - Lansdowne PA
Assignee:
SmithKline Beckman Corporation - Philadelphia PA
International Classification:
C07D26304
US Classification:
548215
Abstract:
New intermediates, namely 2-(2-halo-3,4-dimethoxybenzyl)-5-(4-methoxyphenyl)-oxazolidines, are prepared by a synthetic sequence which uses a Darzen's reaction in a homogeneous solvent system.

Intermediates And Processes Useful For Preparing Medicinal Agents Imidazolemethylphosphonium Salts

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US Patent:
41397088, Feb 13, 1979
Filed:
Mar 8, 1978
Appl. No.:
5/884657
Inventors:
Clifford S. Labaw - Philadelphia PA
Robert L. Webb - West Chester PA
George R. Wellman - Warminster PA
Assignee:
SK&F Lab Co. - Carolina PR
International Classification:
C07F 965
US Classification:
548342
Abstract:
New imidazolemethylphosphonium salts having a degradable group at the 2-position which are useful intermediates for preparing histamine H. sub. 2 antagonists.

Method For Preparing 2-Cyanamidobenzimidazoles Or 2-Cyanamidobenzoxazoles

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US Patent:
43213936, Mar 23, 1982
Filed:
Jan 14, 1981
Appl. No.:
6/224780
Inventors:
Clifford S. Labaw - Philadelphia PA
Robert L. Webb - West Chester PA
Assignee:
SmithKline Corporation - Philadephia PA
International Classification:
C07D23504
US Classification:
548222
Abstract:
A method of preparing 2-cyanamidobenzimidazoles or 2-cyanamidobenzoxazoles comprising reacting N-cyanodiphenoxyiminocarbonate with an o-amino or o-hydroxy aniline.

N-Phenyl-N'-Cyano-O-Phenylisoureas

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US Patent:
42858780, Aug 25, 1981
Filed:
Jan 31, 1980
Appl. No.:
6/117158
Inventors:
Clifford S. Labaw - Philadelphia PA
Robert L. Webb - West Chester PA
Assignee:
SmithKline Corporation - Philadephia PA
International Classification:
C07C11920
US Classification:
2604537
Abstract:
N-Phenyl-N'-cyano-O-phenylisoureas are prepared from N-cyanodiphenoxyimidocarbonate and an optionally substituted o-phenylenediamine or o-aminophenol. The isoureas are new chemical intermediates especially useful for preparing 2-cyanamido and 2-carbomethoxyaminobenzimidazole and benzoxazole compounds having anthelmintic activity.
Clifford S Labaw from Philadelphia, PA, age ~75 Get Report