Inventors:
Christopher S. Brook - King of Prussia PA, US
Pingyun Y. Chen - Indianapolis IN, US
Wei Chen - Woodbury MN, US
Qunying Dai - King of Prussia PA, US
Philip C. Dell'Orco - King of Prussia PA, US
Clifford S. Labaw - King of Prussia PA, US
Ann Marie Diederich - King of Prussia PA, US
Choon K. Oh - Collegeville PA, US
Claire Hisler - Meyzieu, FR
David H. Igo - Research Triangle Park NC, US
Lee M. Katrincic - King of Prussia PA, US
Li-Jen Ping - King of Prussia PA, US
Paul G. Spoors - King of Prussia PA, US
Jun Wang - King of Prussia PA, US
Christopher Werner - King of Prussia PA, US
Assignee:
SB Pharmco Puerto Rico Inc. - Hato Rey PR
International Classification:
A61K 31/403
C07D 209/82
Abstract:
The present invention relates to a salt of carvedilol and/or corresponding solvates thereof, compositions containing such carvedilol and/or corresponding solvates thereof, and/or methods of using the aforementioned compound(s) in the treatment of certain disease states in mammals, in particular man. The present invention further relates to carvedilol phosphate salts, and/or solvates thereof, which include a novel crystalline form of carvedilol dihydrogen phosphate (i. e. , which is the dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy)ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate, etc. ) and/or other corresponding solvates thereof, compositions containing these carvedilol phosphate salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc.