US Patent:
20200054623, Feb 20, 2020
Inventors:
- Atlanta GA, US
Edgars Jecs - Decatur GA, US
Robert James Wilson - Gansevoort NY, US
Huy Hoang Nguyen - Norcross GA, US
Michelle Bora Kim - Chamblee GA, US
Lawrence Wilson - Atlanta GA, US
Eric James Miller - Atlanta GA, US
Yesim Altas Tahirovic - Atlanta GA, US
Valarie Truax - North Haven CT, US
Thomas Kaiser - Bicester, GB
International Classification:
A61K 31/4725
C07D 401/12
C07D 417/12
C07D 401/14
A61K 31/496
C07D 405/14
C07D 413/14
A61K 31/5377
A61K 31/4995
C07D 487/08
C07D 487/04
A61K 31/4985
C07D 471/04
C07D 417/14
A61K 31/541
A61P 35/00
Abstract:
The disclosure relates to chemokine CXCR4 receptor modulators and uses related thereto. The receptor modulators can be formulated to form pharmaceutical compositions comprising the disclosed compounds or pharmaceutically acceptable salts or prodrugs thereof. The compositions may be used for managing CXCR4 related conditions, typically prevention or treatment of viral infections abnormal cellular proliferation, retinal degeneration, inflammatory diseases, or as an immunostimulant or immunosuppressant or for managing cancer and may be administered with another active ingredient such as an antiviral agent or chemotherapeutic agent.