Inventors:
Rudolf P. Buhs - Short Hills NJ
Theodore A. Jacob - Westfield NJ
Gerald Miwa - Maplewood NJ
Elena Sestokas - Rahway NJ
Rae Taub - Metuchen NJ
John S. Walsh - Avenel NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A61K 3171
C07H 1708
Abstract:
There are disclosed certain new derivatives of C-076 compounds which have been isolated from the livers of animals that had been administered ivermectin and the in vitro incubation of such compounds with animal liver preparations. The compounds retain the basic ivermectin structure, however, 24-methyl group has been oxidized to a hydroxy methyl group and, in some of the new compounds the disaccharide substituent of the starting materials has been cleaved to a monosaccharide moiety. The new compounds have been found to retain the biological activity of the parent C-076 compounds. The compounds are thus potent antiparasitic agents and compositions and methods for such uses are also disclosed.