Inventors:
Jacob K. Frenkel - Overland Park KS
Elmer R. Pfefferkorn - Hanover NH
Assignee:
The Kansas University Endowment Association
International Classification:
A61K 39002
Abstract:
A method for the immunization of mammals (including man) and birds, against Toxoplasma gondii is described which involves subcutaneous administration of a live, low-virulent vaccine comprising a temperature-sensitive mutant of the persistent, virulent RH strain of T. gondii. The vaccine gives immunity against subsequent challenge, but does not persist and does not cause chronic infection of the subject and which therefore cannot result in illness or death in the event that the subject later becomes immunosuppressed.