Resumes
Resumes
Eric Pisk Phones & Addresses
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Moneta, VA
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Conshohocken, PA
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Mc Gaheysville, VA
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Baker, WV
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3480 Lake Pointe Dr, Harrisonburg, VA 22801 (540) 432-0384
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3470 Lake Pointe Dr, Harrisonburg, VA 22801
Work
Position:
Professional/Technical
Education
Degree:
Associate degree or higher
Emails
Business Records
Name / Title
Company / Classification
Phones & Addresses
Principal
Lake Shenandoah Preservation Association
Membership Organization
Membership Organization
3480 Lk Pointe Dr, Harrisonburg, VA 22801
Publications
Us Patents
Process For Preparing Acetonides
View pageUS Patent:
6482952, Nov 19, 2002
Filed:
Jun 18, 2001
Appl. No.:
09/883417
Inventors:
Steven J. Cianciosi - Leesburg GA
Gregory L. Tewalt - Lansdale PA
Eric T. Pisk - Harrisonburg VA
Ilia A. Zavialov - East Windsor NJ
Glenn A. Hulvey - Harrisonburg VA
Gregory L. Tewalt - Lansdale PA
Eric T. Pisk - Harrisonburg VA
Ilia A. Zavialov - East Windsor NJ
Glenn A. Hulvey - Harrisonburg VA
Assignee:
Merck Co., Inc. - Rahway NJ
International Classification:
C07D26352
US Classification:
548217
Abstract:
Acetonides are obtained in a one-step reaction of a carboxylic acid halide, a 1,2-aminoalcohol, and 2-alkoxypropene or 2,2-dialkoxypropane in an ether solvent and in the presence of an inorganic base. Acetonides are also obtained in a two-step reaction scheme in which an acid halide and 1,2-aminoalcohol are reacted in an ether solvent in the presence of LiOH to form a hydroxyamide, which is then reacted with 2-alkoxypropene or 2,2-dialkoxypropane in the presence of acid to form the acetonide. The acetonides resulting from the one-step and two-step protocols can be further reacted with an allylating agent such as an allyl halide in the presence of a strong base to provide the corresponding allyl acetonide. The acetonides and allyl acetonides can serve as intermediates in the production of certain HIV protease inhibitors which are useful for treating HIV infection and AIDS.
Biosynthetic Production Of 7-[1',2',6',7',8',8A'(R)-Hexahydro-2'(S),6'(R)-Dimethyl-8'(S)-Hydroxy-1' (S)-Naphthyl]-3(R),5(R)-Dihydroxyheptanoic Acid (Triol Acid)
View pageUS Patent:
52234150, Jun 29, 1993
Filed:
Feb 7, 1992
Appl. No.:
7/832545
Inventors:
Michael J. Conder - Harrisonburg VA
Steven J. Cianciosi - Harrisonburg VA
William H. Cover - Lansdale PA
Rebecca L. Dabora - Andover MA
Eric T. Pisk - Harrisonburg VA
Robert W. Stieber - Harrisonburg VA
Bogdan Tehlewitz - McGaheysville VA
Gregory L. Tewalt - Shenandoah VA
Steven J. Cianciosi - Harrisonburg VA
William H. Cover - Lansdale PA
Rebecca L. Dabora - Andover MA
Eric T. Pisk - Harrisonburg VA
Robert W. Stieber - Harrisonburg VA
Bogdan Tehlewitz - McGaheysville VA
Gregory L. Tewalt - Shenandoah VA
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C12P 1700
C12P 1706
C12N 914
C07D30930
C12P 1706
C12N 914
C07D30930
US Classification:
435125
Abstract:
Biosynthetic production of 7-[1',2',6',-7',8',8a'(R)-hexahydro-2'(S),6'(R)-dimethyl-8'(S)-hydroxy-1'( S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid, "triol acid", is accomplished by enzymatic hydrolysis of lovastatin acid or a salt thereof, by treating it with Clonostachys compactiuscula ATCC 38009 or ATCC 74178, or mutants thereof, or a cell-free extract derived therefrom, or a hydrolase derived therefrom. The triol acid and its lactone form are both inhibitors of HMG-CoA reductase and thus useful as anti-hypercholesterolemic agents, and may also serve as intermediates for preparation of other HMG-CoA reductase inhibitors. Also, in the synthesis of simvastatin by direct methylation of lovastatin, selective hydrolysis of residual lovastatin salt by treatment with Clonostachys compactiuscula ATCC 38009 or ATCC 74178 or mutants thereof or a cell-free extract derived therefrom, or a hydrolase derived therefrom yields the "triol" salt which can be easily separated from simvastatin.