Francis H Gigliotti

7815918, Oct 19, 2010

Dec 31, 2004

10/584871

Francis Gigliotti - Pittsford NY, US
Terry W. Wright - West Henrietta NY, US
Constantine G. Haidaris - Rochester NY, US
Jesse Wells - Rochester NY, US

University of Rochester - Rochester NY

A61K 39/00
A61K 39/38
A61K 38/00
C07K 14/00

4242741, 4241851, 4241841, 514 2, 530350, 530823

A number of immunologically active agents are described, including an isolated protein or polypeptide that includes the amino acid sequence of SEQ ID NO: 1, immunogenic conjugates containing either the protein or polypeptide, a full-length kexin, or a full length pneumococcal surface protein A (PspA), antibodies recognizing the protein or polypeptide or the immunogenic conjugates (particularly the epitope of SEQ ID NO: 1), and nucleic acid molecules that encode the protein or polypeptide, as well as DNA constructs, expression vectors, and host cells that contain the nucleic acid molecules. Disclosed uses of the antibodies, immunogenic conjugates, and DNA constructs include inducing passive or active immunity to treat or prevent pathogen infections, particularly by a organism, in a patient.

46892990, Aug 25, 1987

Sep 22, 1983

6/534658

Richard A. Insel - Rochester NY
Francis Gigliotti - Memphis TN

University of Rochester - Rochester NY

C12N 500
C12N 1500

43524027

The production of stable hybrid cell lines that secrete human monoclonal antibodies against bacterial toxins by fusing post-immunization human peripheral blood lymphocytes with nonsecretor mouse myeloma cells is described. Using the method, protective monoclonal antibodies against tetanus toxin and diphtheria toxin were produced that bind tetanus toxin and diphtheria toxin in vitro, respectively, and prevent tetanus and diphtheria in vivo in animals, respectively.

20140271656, Sep 18, 2014

Aug 6, 2012

14/237133

Francis Gigliotti - Pittsford NY, US
Terry W. Wright - West Henrietta NY, US
Constantine G. Haidaris - Rochester NY, US
Patricia J. Simpson-Haidaris - Rochester NY, US

UNIVERSITY OF ROCHESTER - Rochester NY

C07K 14/44
A61K 39/00
C12N 9/02
C07K 16/20

4241391, 530350, 536 235, 536 234, 4241911, 5303879, 435188, 4353201

Immunologically active agents are described, including isolated A 12 protein or polypeptides; immunogenic conjugates containing A 12 protein or polypeptide of the present invention; antibodies recognizing the A 12 protein or polypeptide or the immunogenic conjugates of the present invention; and nucleic acid molecules that encode the A 12 protein or polypeptide of the present invention, as well as DNA constructs, expression vectors, and host cells that contain the nucleic acid molecules. Disclosed uses of the antibodies, immunogenic conjugates, and DNA constructs include inducing passive or active immunity to treat or prevent pathogen infections, particularly by a organism, in a subject.