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Ihab H Younis

from Pittsburgh, PA
Age ~48
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Also known as:
Younis Younis
Connected to:
Andy YounisHesham Younis, 51Hisham A Younis, 58Houda Y Younis, 51Manhal Y Younis, 62Mariam YounisRasha Younis, 97Saad S Younis, 66Jeffrey J Youniss, 58Lauren T Younker, 46

Ihab Younis Phones & Addresses

  • Pittsburgh, PA
  • Philadelphia, PA
  • 484 Stinchcomb Dr, Columbus, OH 43202 (614) 261-7281
  • 484 Stinchcomb Dr #35, Columbus, OH 43202 (614) 261-7281
  • 333 8Th St, Columbus, OH 43201 (614) 424-6914
  • Henderson, IL
  • 484 Stinchcomb Dr, Columbus, OH 43202 (614) 440-5310

Work

Company: University of pennsylvania Oct 2005 Position: Research associate

Education

Degree: PhD School / High School: The Ohio State University 2000 to 2005 Specialities: Molecular and Cellular Biology

Languages

Arabic

Emails

i***[email protected]

Industries

Higher Education

Resumes

Resumes

Ihab Younis Photo 1

Research Associate At University Of Pennsylvania

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Position:
Research Associate at University of Pennsylvania, Research Associate at Howard Hughes Medical Institute
Location:
Greater Philadelphia Area
Industry:
Higher Education
Work:
University of Pennsylvania since Oct 2005
Research Associate
Howard Hughes Medical Institute since 2005
Research Associate
The Ohio State University 2000 - 2005
Graduate Student
Education:
The Ohio State University 2000 - 2005
PhD, Molecular and Cellular Biology American University of Beirut 1997 - 1999
MSc, Biology American University of Beirut 1993 - 1997
BSc, Biology
Languages:
Arabic

Publications

Us Patents

Methods Of Identifying And Using General Or Alternative Splicing Inhibitors

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US Patent:
20120157474, Jun 21, 2012
Filed:
May 21, 2010
Appl. No.:
13/321849
Inventors:
Gideon Dreyfuss - Wynnewood PA, US
Ihab Younis - Philadelphia PA, US
Lili Wan - Westfield NJ, US
Assignee:
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA - Philadelphia, PA
International Classification:
A61K 31/495
C12N 5/071
A61K 31/4174
C40B 30/04
C07D 241/04
A61K 31/155
C07C 279/26
G01N 21/75
C12Q 1/68
C07D 233/62
US Classification:
51425504, 435 612, 435375, 514396, 5483461, 544396, 514634, 564236, 436501, 506 9
Abstract:
The present invention is based on the discovery of a cell-based system to identify novel modulators of splicing or splicing dependent processes. The cell-based system of the present invention utilizes a fast and highly sensitive reporter, that responds to defects in the splicing machinery itself and is sensitive to changes in the signals that regulate splicing dependent processes such as those that modulate the EJC, splicing-dependent export, localization or translation efficiency. The present invention further uses the cell-based screen to identify several small molecules that modulate both constitutive and alternative splicing. Accordingly, the present invention includes general or alternative splicing inhibitors identified using the assay described herein. The present invention also provides methods of treating a subject having a condition associated with aberrant target RNA expression. The present invention further details a kit that may be directed to specifically detecting a general or alternative splicing inhibitor of the invention.

U1 Snrnp Regulates Gene Expression And Modulates Oncogenicity

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US Patent:
20150191724, Jul 9, 2015
Filed:
Jul 5, 2013
Appl. No.:
14/412821
Inventors:
- Philadelphia PA, US
Lili Wan - Westfield NJ, US
Jung Min Oh - Philadelphia PA, US
Anna Maria Pinto - Philadelphia PA, US
Ihab Younis - Philadelphia PA, US
Michael George Berg - Northbrook IL, US
Daisuke Kaida - Toyanna, JP
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
C12N 15/113
Abstract:
The present invention relates to the discovery of a novel global gene expression regulation mechanism whereby U1 snRNP (U1) protects pre-mRNAs. In one embodiment, the invention includes compositions and methods for regulating gene expression and treating diseases associated with dysregulated gene expression.
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Ihab H Younis from Pittsburgh, PA, age ~48 Get Report