Inventors:
Maria Emilia DiFrancesco - Houston TX, US
Alessia Petrocchi - Houston TX, US
Christopher L. Carroll - Houston TX, US
Joe Marszalek - Houston TX, US
Barbara Czako - Houston TX, US
Ryan Johnson - Houston TX, US
Jay Theroff - Houston TX, US
Assignee:
Institute For Applied Cancer Science/The University of Texas MD Anderson Cancer Center - Houston TX
International Classification:
C07D 413/04
C07D 417/14
A61K 31/454
A61K 45/06
A61K 31/496
C07D 413/14
C07D 417/04
US Classification:
51421018, 5142362, 51425403, 5142531, 514256, 514274, 514275, 514340, 514364, 514365, 514374, 544137, 544138, 544316, 544331, 544333, 544364, 544367, 544369, 5462691, 548124, 548131, 548205, 548235, 546176, 546194, 514314, 514318
Abstract:
The present invention relates to compounds and methods which may be useful as inhibitors of HIF pathway activity for the treatment or prevention of cancer and other hypoxia-mediated diseases.