US Patent:
20040019210, Jan 29, 2004
Inventors:
Cleo Chivikas Connolly - Livonia MI, US
Christopher Deur - Ann Arbor MI, US
James Hamby - Ann Arbor MI, US
Denton Hoyer - Dexter MI, US
Chris Limberakis - Saline MI, US
Jessica Reed - Ann Arbor MI, US
Mel Schroeder - Dexter MI, US
Clarke Taylor - Ann Arbor MI, US
International Classification:
C07D487/02
C07D475/02
C 07D 4 3/02
US Classification:
544/256000, 544/257000, 544/284000, 544/350000, 544/363000
Abstract:
This invention provides phenyl-substituted pyrimidopyrimidines, dihydropyrimido-pyrimidines, pyridopyrimidines, naphthyridines, and pyridopyrazines of the general formula: that inhibit cyclin-dependent kinase and tyrosine kinase enzymes, methods and intermediate compounds for their synthesis, as well as pharmaceutical compositions and methods for their use in treating, inhibiting or preventing maladies associated with cell proliferative disorders, including angiogenesis, atherosclerosis, restenosis, and cancer.