Jianxin J Gao

7947511, May 24, 2011

Jun 5, 2009

12/479283

Poguang Wang - Westborough MA, US
Guodong Li - Malden MA, US
Jianxin Gao - Dorchester MA, US
Roger W. Giese - Quincy MA, US
Xin Zhang - Brookline MA, US

Northeastern University - Boston MA

C07D 207/40
G01N 33/48
B01D 59/44

436173, 548545, 436 86, 436 87, 436 94, 436 96

Ultrasensitive detection of a chemical substance (analyte) by mass spectrometry is achieved by employing a molecular tag that yields an intense parent ion and then an intense daughter ion in a multi-stage mass spectrometer.

8367734, Feb 5, 2013

May 7, 2010

12/776338

Jianxin Gao - Norton MA, US
James Luo - Quincy MA, US
Rong Zhou - Fullerton CA, US
Mary Ziping Luo - Diamond Bar CA, US
Jack Yongfeng Zhang - Diamond Bar CA, US

Amphastar Pharmaceuticals Inc. - Rancho Cucamonga CA

A61K 31/135
A61K 31/05
A61K 9/12
A61K 9/14

514653, 514728, 424 45, 424 46, 424489

A stable suspension aerosol formulation of epinephrine is suitable for administration through inhalation comprising a therapeutically effective amount of epinephrine, hydrofluorocarbon propellant, co-solvent, surfactant, and antioxidant. The suspension aerosol formulation further comprises [pre-] pre-micronized epinephrine suspended in an alcohol/surfactant solution with hydrofluoroalkane propellant. The suspension formulation provides a highly efficient delivery of drug microparticles into the respirable region of patients' lungs and has the following advantages: lower dosage requirement, minimum alcohol content, with less impurities generated during storage, improved efficacy and safety, and exhibits no ozone depleting potential compared to a formulation containing chlorofluorocarbon.

20040054195, Mar 18, 2004

Jul 10, 2003

10/250975

Jianxin Gao - Dorchester MA, US
Roger Giese - Quincy MA, US

C07D311/82

549/223000

Secondary amide xanthene derivatives, termed “xanthamides”, and other xanthene derivatives, are obtained in one form as fluorescent dyes which can have much higher photostability than related dyes such as fluorescein and BODIPY-FL. Examples are presented in which the synthesis begins with 5-carboxyfluorescein, an inexpensive reagent. Related carboxyxanthenes employed in other dyes such as rhodamines can also be used as starting materials. Simple synthetic steps yield compounds which exemplify this invention. Other notable properties of the xanthamide dyes include the option of pH-independent fluorescence, and the ease of controlling their functional and other groups. This means that a diversity of xanthamide and related xanthene dyes can be prepared with a broad variation of physicochemical properties to enhance the usefulness of fluorescence in biological and chemical analysis, and in other areas. In a second form xanthamides are formed which can be used as precursors of xanthamide dyes, especially as indicators or quenchers of reactive oxygen or free radical species.

20040157344, Aug 12, 2004

Dec 19, 2003

10/741585

Poguang Wang - Westborough MA, US
Guodong Li - Malden MA, US
Jianxin Gao - Dorchester MA, US
Roger Giese - Quincy MA, US

G01N033/543
C07K014/47
C07F007/04
C07F009/02

436/518000, 530/409000, 556/404000, 556/415000, 564/282000, 530/352000, 568/009000

Ultrasensitive detection of a chemical substance (analyte) by mass spectrometry is achieved by employing a molecular tag that yields an intense parent ion and then an intense daughter ion in a multi-stage mass spectrometer.