Inventors:
Douglas Beight - Frankfort IN, US
Todd DeCollo - Noblesville IN, US
Alexander Godfrey - Greenwood IN, US
Theodore Goodson - Indianapolis IN, US
Hong-Yu Li - Zionsville IN, US
William McMillen - Indianapolis IN, US
Shawn Miller - Noblesville IN, US
Jason Sawyer - Indianapolis IN, US
Edward Smith - Fishers IN, US
Jonathan Yingling - Fishers IN, US
International Classification:
A61K031/542
A61K031/538
A61K031/4745
C07D498/04
C07D491/04
US Classification:
514/224200, 514/230500, 514/303000, 544/048000, 544/105000, 546/119000
Abstract:
Novel pyrrazole derivative compounds and their use as pharmaceutical agents, in particular their use as TGF-beta signal transduction inhibitors. The disclosed invention relates to compounds of the structure (I) wherein (I) is a four, five, or six membered saturated ring and X is C, O or S.