US Patent:
20190144546, May 16, 2019
Inventors:
- South San Francisco CA, US
Alice YAM - Tiburon CA, US
Avinash GILL - Emeryville CA, US
Kalyani PENTA - Palo Alto CA, US
Xiaofan LI - Fremont CA, US
Aaron SATO - Burlingame CA, US
International Classification:
C07K 16/28
A61P 35/00
A61K 47/68
Abstract:
Provided herein are antibody conjugates with binding specificity for CD74, wherein the antibody comprises a non-natural amino acid at a site selected from the group consisting of HC-F404, HC-K121, HC-Y180, HC-F241, HC-221, LC-T22, LC-S7, LC-N152, LC-K42, LC-E161, LC-D170, HC-S136, HC-525, HC-A40, HC-S119, HC-S190, HC-K222, HC-R19, HC-Y52, or HC-S70, according to the Kabat, Chothia, or EU numbering scheme, and compositions comprising the antibody conjugates, including pharmaceutical compositions, methods of producing the conjugates, and methods of using the conjugates and compositions for therapy.