Kevin M Hennessey

6617445, Sep 9, 2003

Oct 11, 2001

09/976842

Scott C. Benson - Alameda CA
Steven M. Menchen - Fremont CA
Peter D. Theisen - Reno NV
Kevin M. Hennessey - San Mateo CA
Vergine C. Furniss - San Mateo CA
Joan Hauser - Oakland CA

Applera Corporation - Foster City CA

C07H 1904

536 266, 536 2534, 549223, 549224, 544105

A class of asymmetric monobenzoxanthene compounds useful as fluorescent dyes are disclosed having the structure wherein Y and Y are individually hydroxyl, amino, imminium, or oxygen, R -R are hydrogen, fluorine, chlorine, alkyl, alkene, alkyne, sulfonate, amino, amido, nitrile, alkoxy, linking group, and combinations thereof and R is acetylene, alkane, alkene, cyano, substituted phenyl, and combinations thereof. The invention further includes novel intermediate compounds useful for the synthesis of asymmetric benzoxanthene compounds having the general structure where substituents R -R correspond to like-referenced substituents in the structure of described above, and Y is hydroxyl or amine. In another aspect the invention includes methods for synthesizing the above dye compounds and intermediates. In yet another aspect, the present invention includes reagents labeled with the asymmetric benzoxanthene dye compounds, including deoxynucleotides, dideoxynucleotides, phosphoramidites, and polynucleotides.

7179906, Feb 20, 2007

Sep 5, 2003

10/656826

Scott C. Benson - Alameda CA, US
Steven M. Menchen - Fremont CA, US
Peter D. Theisen - Reno NV, US
Kevin M. Hennessey - San Mateo CA, US
Vergine C. Furniss - San Jose CA, US
Joan D. Hauser - Oakland CA, US

Applera Corporation - Foster City CA

C07H 19/04
C07D 311/78
C07D 311/82

536 266, 549223, 549224

A class of asymmetric monobenzoxanthene compounds useful as fluorescent dyes are disclosed having the structure.

60204818, Feb 1, 2000

Apr 1, 1996

8/626085

Scott C. Benson - Oakland CA
Steven M. Menchen - Fremont CA
Peter D. Theisen - South San Francisco CA
Kevin M. Hennessey - San Mateo CA
Vergine C. Furniss - San Mateo CA
Joan Hauser - Oakland CA

The Perkin-Elmer Corporation - Foster City CA

C07H 2104

536 266

A class of asymmetric monobenzoxanthene compounds useful as fluorescent dyes are disclosed having the structure ##STR1## wherein Y. sub. 1 and Y. sub. 2 are individually hydroxyl amino, imminium, or oxygen, R. sub. 1 -R. sub. 8 are hydrogen, fluorine, chlorine, alkyl, alkene, alkyne, sulfonate, amino, amido, nitrile, alkoxy, linking group, and combinations thereof, and R. sub. 9 is acetylene, alkane, alkene, cyano, substituted phenyl, and combinations thereof. The invention further includes novel intermediate compounds useful for the synthesis of asymmetric benzoxanthene compounds having the general structure ##STR2## where substituents R. sub. 3 -R. sub. 7 correspond to like-referenced substituents in the structure of described above, and Y. sub. 2 is hydroxyl or amine. In another aspect, the invention includes methods for synthesizing the above dye compounds and intermediates.

63037750, Oct 16, 2001

Feb 1, 2000

9/495111

Scott C. Benson - Oakland CA
Steven M. Menchen - Fremont CA
Peter D. Theisen - South San Francisco CA
Kevin M. Hennessey - San Mateo CA
Vergine C. Furniss - San Mateo CA
Joan Hauser - Oakland CA

The Perkin-Elmer Corporation - Foster City CA

C07H 2104

536 266

A class of asymmetric monobenzoxanthene compounds useful as fluorescent dyes are disclosed having the structure ##STR1## wherein Y. sub. 1 and Y. sub. 2 are individually hydroxyl, amino, imminium, or oxygen, R. sub. 1 -R. sub. 8 are hydrogen, fluorine, chlorine, alkyl, alkene, alkyne, sulfonate, amino, amido, nitrile, alkoxy, linking group, and combinations thereof, and R. sub. 9 is acetylene, alkane, alkene, cyano, substituted phenyl, and combinations thereof. The invention further includes novel intermediate compounds useful for the synthesis of asymmetric benzoxanthene compounds having the general structure ##STR2## where substituents R. sub. 3 -R. sub. 7 correspond to like-referenced substituents in the structure of described above, and Y. sub. 2 is hydroxyl or amine. In another aspect, the invention includes methods for synthesizing the above dye compounds and intermediates.

58409998, Nov 24, 1998

Mar 26, 1997

8/824102

Scott C. Benson - Oakland CA
Steven M. Menchen - Fremont CA
Peter D. Theisen - South San Francisco CA
Kevin M. Hennessey - San Mateo CA
Vergine C. Furniss - San Mateo CA
Joan Hauser - Oakland CA

The Perkin-Elmer Corporation - Foster City CA

C07C 3914
C07C 3768

568735

A class of asymmetric monobenzoxanthene compounds useful as fluorescent dyes are disclosed having the structure ##STR1## wherein Y. sub. 1, and Y. sub. 2 are individually hydroxyl, amino, imminium, or oxygen, R. sub. 1 -R. sub. 8 are hydrogen, fluorine, chlorine, alkyl alkene, alkyne, sulfonate, amino, amido, nitrile, alkoxy, linking group, and combinations thereof, and R. sub. 9 is acetylene, alkane, alkene, cyano, substituted phenyl and combinations thereof The invention ftrther includes novel intermediate compounds useful for the synthesis of asymmetric benzoxanthene compounds having the general structure ##STR2## where substituents R. sub. 3 -R. sub. 7 correspond to like-referenced substituents in the structure of described above, and Y. sub. 2 is hydroxyl or amine. In another aspect, the invention includes methods for synthesizing the above dye compounds and intermediates.