US Patent:
20120238937, Sep 20, 2012
Inventors:
Nicholas M. Dean - Encinitas CA, US
Lincoln Krochmal - Los Gatos CA, US
Gregory Hardee - Del Mar CA, US
J. Gordon Foulkes - Encinitas CA, US
Niall O'Donnell - Encinitas CA, US
Leroy Young - Wildwood MO, US
Mark Jewell - Eugene OR, US
International Classification:
A61K 31/7088
A61K 31/713
A61K 31/7105
A61K 31/711
A61M 5/00
A61K 31/712
A61K 31/7115
A61M 37/00
A61N 1/30
A61P 17/02
A61K 31/7125
US Classification:
604 20, 514 44 A, 604 22, 604506
Abstract:
This invention provides methods of preventing formation of, or treating, fibrotic lesions, including skin scars such as keloids and hypertrophic scars which comprise administering to the subject by one or more injection a compound which comprises a modified oligonucleotide, such as a modified antisense oligonucleotide, siRNA, or oligodeoxyribonucleotide, which inhibits expression of protein involved in fibrosis. Dosing of the antisense using an intradermal threading technique is also described.