Inventors:
Rex M. Bitner - Cedarburg WI, US
Mark A. Denhart - Madison WI, US
Donald B. Smith - Evansville WI, US
Assignee:
PROMEGA CORPORATION - MADISON WI
International Classification:
C07H 1/08
C07H 21/02
C12N 9/99
Abstract:
The present invention relates to methods, kits, and compositions for purifying small RNA molecules. In particular, the present invention provides methods for purifying small RNA molecules from a sample containing both small RNA molecules and larger RNA molecules using a compaction agent and a RNA binding matrix, as well as compositions and kits for practicing such methods. In certain embodiments, the compaction agent comprises a plurality of metal-amine-halide molecules.