Resumes
Resumes
Max Oeschger Phones & Addresses
-
Silver Spring, MD
Publications
Us Patents
Genetically Attenuated Bacterial Vaccines With Multiple Mutations Of The Same Phenotype
View pageUS Patent:
46817620, Jul 21, 1987
Filed:
Feb 16, 1984
Appl. No.:
6/580588
Inventors:
Max P. Oeschger - Silver Spring MD
Anne M. Hooke - Annandale VA
Joseph A. Bellanti - Bethesda MD
Anne M. Hooke - Annandale VA
Joseph A. Bellanti - Bethesda MD
Assignee:
Research Corporation - New York NY
International Classification:
A61K 39102
A61K 3902
C12N 1500
C12N 120
A61K 3902
C12N 1500
C12N 120
US Classification:
424 92
Abstract:
The present invention relates to a vaccine composition for the prevention of infectious diseases comprising an immunogenically-effective amount of a genetically attenuated and stable avirulent bacterial strain derived from a virulent bacterial strain by introducing into said virulent strain by genetic transfer and recombination at least two mutations of the same phenotype which renders said virulent strain avirulent, while permitting said avirulent strain to retain immunogenicity, together with an inert pharmacologically acceptable carrier. It also relates to a method for preparing the vaccine.
Genetically Attenuated Bacterial Vaccines With Multiple Mutations Of The Same Phenotype
View pageUS Patent:
43373143, Jun 29, 1982
Filed:
May 23, 1979
Appl. No.:
6/041896
Inventors:
Max P. Oeschger - Silver Spring MD
Anne M. Hooke - Annandale VA
Joseph A. Bellanti - Bethesda MD
Anne M. Hooke - Annandale VA
Joseph A. Bellanti - Bethesda MD
Assignee:
Research Corporation - New York NY
International Classification:
C12N 120
US Classification:
435253
Abstract:
A vaccine composition comprising a genetically attenuated bacterial strain which contains at least two mutations of the same phenotype which strain is rendered avirulent while retaining immunogenicity.