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Michael P Terns

from Athens, GA
Age ~62
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Related to:
Rebecca M Terns, 60Rachel TernsR Terns, 60R TernsCarl TernsStephen Jessen, 65
Connected to:
Giuseppe Ternullo, 88Jane W Ternus, 76Amelia V Tero, 81Marilyn H Tero, 62Rita E Tero, 79Robert R Tero, 55Ani Teroganesyan, 38Alex TeronAlfred C Terone, 108

Michael Terns Phones & Addresses

  • 235 Tamarack Dr, Athens, GA 30605 (706) 546-8884
  • Madison, WI
  • Evanston, IL
  • Virginia Bch, VA

Work

Company: University of georgia Dec 31, 1995 Position: Distinguished research professor

Education

School / High School: University of Wisconsin - Madison 1990 to 1995

Skills

Biochemistry • Molecular Biology • Molecular Cloning • Polymerase Chain Reaction • Cell Biology • Cell Culture • Genetics • Pcr • Protein Chemistry • Western Blotting

Industries

Biotechnology

Resumes

Resumes

Michael Terns Photo 1

Professor

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Location:
Athens, GA
Industry:
Biotechnology
Work:
University of Georgia
Distinguished Research Professor
Uga
Professor
Education:
University of Wisconsin - Madison 1990 - 1995
Penn State University
Stevenson High School
University of Wisconsin - Madison
University of Michigan
Skills:
Biochemistry
Molecular Biology
Molecular Cloning
Polymerase Chain Reaction
Cell Biology
Cell Culture
Genetics
Pcr
Protein Chemistry
Western Blotting

Publications

Us Patents

Prokaryotic Rnai-Like System And Methods Of Use

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US Patent:
20110189776, Aug 4, 2011
Filed:
Jul 24, 2009
Appl. No.:
13/055769
Inventors:
Rebecca Terns - Athens GA, US
Michael Terns - Athens GA, US
Caryn Hale - Athens GA, US
Assignee:
University of Georgia Research Foundation, Inc. - Athens GA
International Classification:
C12N 15/74
C12N 15/63
C07H 21/02
US Classification:
435471, 4353201, 536 231
Abstract:
Provided herein are methods for inactivating a target polynucleotide. The methods use a psiRNA having a 5′ region and a 3′ region. The 5′ region includes, but is not limited to, 5 to 10 nucleotides chosen from a repeat from a CRISPR locus immediately upstream of a spacer. The 3′ region is substantially complementary to a portion of the target polynucleotide. The methods may be practiced in a prokaryotic microbe or in vitro. Also provided are polypeptides that have endonuclease activity in the presence of a psiRNA and a target polynucleotide, and methods for using the polypeptides.

Cas6 Polypeptides And Methods Of Use

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US Patent:
20110217739, Sep 8, 2011
Filed:
Nov 5, 2009
Appl. No.:
13/127764
Inventors:
Rebecca M. Terns - Athens GA, US
Michael P. Terns - Athens GA, US
Jason Carte - Athens GA, US
Assignee:
University of Georgia Research Foundation, Inc. - Athens GA
International Classification:
C12P 19/34
C12N 1/00
C12N 9/22
C12N 1/21
US Classification:
435 9151, 435243, 435199, 43525233, 4352523, 435 911
Abstract:
Provided herein are methods for cleaving a target RNA polynucleotide. The target RNA polynucleotide includes a Cas6 recognition domain and a cleavage site, and may be based on a repeat from a CRISPR locus. The methods may be practiced in vivo or in vitro. Also provided are polypeptides that have Cas6 endoribonuclease activity in the presence of a target RNA polynucleotide, and methods for using the polypeptides.

Methods For Cleaving Dna And Rna Molecules

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US Patent:
20190161753, May 30, 2019
Filed:
Jan 6, 2017
Appl. No.:
16/065236
Inventors:
- Athens GA, US
Michael P. Terns - Athens GA, US
Joshua R. Elmore - Knoxville TN, US
International Classification:
C12N 15/113
C12N 15/11
C12N 9/22
C12N 1/20
Abstract:
Provided herein is a programmable RNA-activated DNA endonuclease activity associated with a Cmr complex. In one embodiment, the enzyme is a general double-stranded DNA endonuclease. Also provided is a programmable RNA endonuclease activity associated with a Cmr complex. In one embodiment, a Cmr2 protein present in a Cmr complex includes a mutation that reduces RNA-activated DNAse activity of the Cmr complex. In one embodiment, a Cmr4 protein present in a Cmr complex includes a mutation that reduces the RNase activity of the Cmr complex. Compositions including components of a Cmr complex and a CRIS-PR-RNA, and an optional activating RNA, are provided. Also provided are methods for using the compositions, and genetically engineered cells that include components of a Cmr complex and a CRISPR-RNA, and an optional activating RNA.

Adenosine-Specific Rnase And Methods Of Use

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US Patent:
20170191047, Jul 6, 2017
Filed:
Nov 16, 2016
Appl. No.:
15/353559
Inventors:
- Athens GA, US
Michael P. Terns - Athens GA, US
Nolan F. Sheppard - West Orange NJ, US
International Classification:
C12N 9/22
C12Q 1/68
Abstract:
Provided herein are proteins having A-specific RNase activity. A protein having A-specific RNAse activity is referred to herein as a Csx protein. A Csx protein is an endoribonuclease, and has the activity of cleaving the phosphodiester bond in a single strand of a target RNA molecule on the 3′ (downstream) side of an adenosine base to result in a first cleavage product having a 5′ hydroxyl group and a second cleavage product having a 2′,3′-cyclic phosphate at the 3′ end. Also provided herein are methods for using a Csx protein. In one embodiment, the method includes incubating a sample that includes an isolated Csx protein and a target RNA molecule under suitable conditions for cleavage of the target RNA molecule. Also provided is a genetically modified microbe that includes an exogenous polynucleotide including a nucleotide sequence encoding a Csx protein, and a method for making Cxsl protein.

Prokaryotic Rnai-Like System And Methods Of Use

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US Patent:
20160355816, Dec 8, 2016
Filed:
Jun 14, 2016
Appl. No.:
15/181718
Inventors:
- Athens GA, US
Michael P. Terns - Athens GA, US
Caryn R. Hale - Athens GA, US
International Classification:
C12N 15/113
Abstract:
Provided herein are methods for inactivating a target polynucleotide. The methods use a psiRNA having a 5′ region and a 3′ region. The 5′ region includes, but is not limited to, 5 to 10 nucleotides chosen from a repeat from a CRISPR locus immediately upstream of a spacer. The 3′ region is substantially complementary to a portion of the target polynucleotide. The methods may be practiced in a prokaryotic microbe or in vitro. Also provided are polypeptides that have endonuclease activity in the presence of a psiRNA and a target polynucleotide, and methods for using the polypeptides.

Prokaryotic Rnai-Like System And Methods Of Use

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US Patent:
20140093941, Apr 3, 2014
Filed:
Sep 12, 2013
Appl. No.:
14/025015
Inventors:
- Athens GA, US
MICHAEL P. TERNS - ATHENS GA, US
CARYN R. HALE - ATHENS GA, US
Assignee:
University of Georgia Research Foundation, Inc. - Athens GA
International Classification:
C12N 15/113
US Classification:
4352521
Abstract:
Provided herein are methods for inactivating a target polynucleotide. The methods use a psiRNA having a 5′ region and a 3′ region. The 5′ region includes, but is not limited to, 5 to 10 nucleotides chosen from a repeat from a CRISPR locus immediately upstream of a spacer. The 3′ region is substantially complementary to a portion of the target polynucleotide. The methods may be practiced in a prokaryotic microbe or in vitro. Also provided are polypeptides that have endonuclease activity in the presence of a psiRNA and a target polynucleotide, and methods for using the polypeptides.
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Michael P Terns from Athens, GA, age ~62 Get Report