Inventors:
Huei-Mei Chen - Richmond CA
Mina Bissell - Berkeley CA
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
G01N 33574
US Classification:
435 723, 435 4, 435 6, 435 721, 435 84, 435 85, 435 89, 435 911, 435 912, 436 63, 436 64, 436501, 424 91, 424 92, 4241301, 4241381, 530300, 530350, 530386, 5303871, 5303879, 5303881, 53038815, 5303891, 5303897
Abstract:
A human AZU-1 gene, mutants, variants and fragments thereof. Protein products encoded by the AZU-1 gene and homologs encoded by the variants of AZU-1 gene acting as tumor suppressors or markers of malignancy progression and tumorigenicity reversion. Identification, isolation and characterization of AZU-1 and AZU-2 genes localized to a tumor suppressive locus at chromosome 10q26, highly expressed in nonmalignant and premalignant cells derived from a human breast tumor progression model. A recombinant full length protein sequences encoded by the AZU-1 gene and nucleotide sequences of AZU-1 and AZU-2 genes and variant and fragments thereof. Monoclonal or polyclonal antibodies specific to AZU-1, AZU-2 encoded protein and to AZU-1, or AZU-2 encoded protein homologs.