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Paul F Agris

from Raleigh, NC
Age ~79
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Also known as:
Paul Dr Agris, Paul J Agris
Phone and address:
6241 Bayswater Trl, Raleigh, NC 27612
(919) 510-0935
Related to:
John A Cole, 92Robert J Agris, 81Laurel AgrisNicholas R Agris, 39Joyce L Agris, 78Theresa A Bodkin, 67Laurel A Agris, 58
Connected to:
Anthony J Agrisula, 59Dorothy N Agro, 57Michael H Agron, 75Maria L Agront, 91Sergey A Agroskin, 42Christopher A Agrusti, 55Craig D Agrusti, 51Mary J Agtang, 30Mary R Agtarap, 50Charity N Agu, 64

Paul Agris Phones & Addresses

  • 6241 Bayswater Trl, Raleigh, NC 27612 (919) 510-0935 (919) 510-1935 (919) 782-9212
  • Columbia, MO
  • Albany, NY
  • 6241 Bayswater Trl, Raleigh, NC 27612 (919) 510-0935

Work

Position: Production Occupations

Education

Degree: High school graduate or higher

Resumes

Resumes

Paul Agris Photo 1

Professor, Biological Sciences And Chemistry

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Work:
The Rna Institute 2009 - 2015
Director
North Carolina State University 1988 - 2010
Professor, Department of Biochemistry
The Rna Institute University at Albany 1988 - 2010
Founding Director
University at Albany 1988 - 2010
Professor, Biological Sciences and Chemistry
The Rna Modification Database 1988 - 2010
Director
Education:
Massachusetts Institute of Technology 1971 - 1971
Doctorates, Doctor of Philosophy, Biochemistry, Philosophy Bucknell University 1966 - 1966
Bachelors, Biology, Chemistry
Paul Agris Photo 2

Professor

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Location:
Durham, NC
Industry:
Philanthropy
Work:
NCSU
Professor
Paul Agris Photo 3

Professor

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Location:
180 south Main St, Mocksville, NC 27028
Industry:
Pharmaceuticals
Work:
Sirga Advanced Biopharma
Owner
North Carolina State University
Professor
Education:
Massachusetts Institute of Technology 1966 - 1971

Publications

Us Patents

Methods And Compositions For Determining The Purity Of Chemically Synthesized Nucleic Acids

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US Patent:
6929907, Aug 16, 2005
Filed:
Dec 22, 2000
Appl. No.:
09/747467
Inventors:
Paul F. Agris - Raleigh NC, US
Assignee:
North Carolina State University - Raleigh NC
International Classification:
C12Q001/68
C12P019/34
C07K017/00
US Classification:
435 6, 435 911, 4241861, 4241881, 530334, 530333, 536 27, 536 28, 536 29
Abstract:
This application describes an antibody that specifically binds to a synthetic oligomer (e. g. , an oligonucleotide or oligopeptide) having a organic protecting group covalently bound thereto, which antibody does not bind to that synthetic oligomer when the organic protecting group is not covalently bound thereto. Methods of making and using such antibodies are also disclosed, along with cells for making such antibodies and articles carrying immobilized oligomers that can be used in assay procedures with such antibodies.

Antibacterial And Antiviral Agents And Methods Of Screening For The Same

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US Patent:
6962785, Nov 8, 2005
Filed:
Aug 6, 2002
Appl. No.:
10/212905
Inventors:
Paul F. Agris - Raleigh NC, US
Salman Ashraf - Raleigh NC, US
Assignee:
North Carolina State University - Raleigh NC
International Classification:
C12Q001/68
C07H021/02
C07H021/04
US Classification:
435 6, 536 231, 536 241
Abstract:
A method of screening for compounds useful for inhibiting retrovirus propagation in a host for the retrovirus, wherein the retrovirus primes reverse transcription in the host by binding of a specific host tRNA to retrovirus RNA at at least a pair of separate binding sites on the host tRNA, comprises contacting the specific host tRNA to the retrovirus RNA in the presence of the test compound, and then determining whether the compound inhibits the binding of the specific host tRNA to the retrovirus RNA in the presence of the test compound.

Methods And Compositions For Determining The Purity Of Chemically Synthesized Nucleic Acids

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US Patent:
7901892, Mar 8, 2011
Filed:
Jul 8, 2002
Appl. No.:
10/190795
Inventors:
Paul F. Agris - Raleigh NC, US
Christopher D. J. Pearce - Surrey, GB
Lloyd G. Mitchell - Durham NC, US
Assignee:
North Carolina State University - Raleigh NC
International Classification:
G01N 33/53
US Classification:
435 71, 435 6
Abstract:
This application describes an antibody that specifically binds to a synthetic oligomer (e. g. , an oligonucleotide or oligopeptide) having a organic protecting group covalently bound thereto, which antibody does not bind to that synthetic oligomer when the organic protecting group is not covalently bound thereto. Methods of making and using such antibodies are also disclosed, along with cells for making such antibodies and articles carrying immobilized oligomers that can be used in assay procedures with such antibodies.

Methods And Compositions For Determining The Purity Of Chemically Synthesized Nucleic Acids

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US Patent:
8173377, May 8, 2012
Filed:
Jan 28, 2011
Appl. No.:
13/016409
Inventors:
Paul F. Agris - Raleigh NC, US
Christopher D. J. Pearce - Surrey, GB
Lloyd G. Mitchell - Durham NC, US
Assignee:
North Carolina State University - Raleigh NC
International Classification:
G01N 33/53
US Classification:
435 71, 435 72, 435518
Abstract:
This application describes an antibody that specifically binds to a synthetic oligomer (e. g. , an oligonucleotide or oligopeptide) having a organic protecting group covalently bound thereto, which antibody does not bind to that synthetic oligomer when the organic protecting group is not covalently bound thereto. Methods of making and using such antibodies are also disclosed, along with cells for making such antibodies and articles carrying immobilized oligomers that can be used in assay procedures with such antibodies.

Methods And Compositions For Determining The Purity Of Chemically Synthesized Nucleic Acids

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US Patent:
8323910, Dec 4, 2012
Filed:
Apr 5, 2012
Appl. No.:
13/440613
Inventors:
Paul F. Agris - Raleigh NC, US
Christopher D. J. Pearce - Surrey, GB
Lloyd G. Mitchell - Durham NC, US
Assignee:
North Carolina State University - Raleigh NC
International Classification:
G01N 33/53
US Classification:
435 71, 436518
Abstract:
This application describes an antibody that specifically binds to a synthetic oligomer (e. g. , an oligonucleotide or oligopeptide) having a organic protecting group covalently bound thereto, which antibody does not bind to that synthetic oligomer when the organic protecting group is not covalently bound thereto. Methods of making and using such antibodies are also disclosed, along with cells for making such antibodies and articles carrying immobilized oligomers that can be used in assay procedures with such antibodies.

Peptides And Methods Of Use As Therapeutics And Screening Agents

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US Patent:
8609609, Dec 17, 2013
Filed:
Jan 16, 2009
Appl. No.:
12/812802
Inventors:
Paul F. Agris - Raleigh NC, US
Assignee:
North Carolina State University - Raleigh NC
International Classification:
A61K 38/00
US Classification:
514 38, 514 11, 530300, 530326, 530328, 530332
Abstract:
Host RNA/viral protein interaction as a target of intervention in the replication of viruses, e. g. , the human immunodeficiency virus (HIV) are described. The target being upstream of the final replication product, and being crucial to the viral replication, is less likely to be genetically altered to drug resistance. Peptides that intervene in this RNA/viral protein interaction are also described, as well as compositions containing the same and methods of use thereof.

Screen For Anti-Infective Compounds

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US Patent:
20080026389, Jan 31, 2008
Filed:
May 18, 2007
Appl. No.:
11/750558
Inventors:
Paul Agris - Raleigh NC, US
International Classification:
C12Q 1/68
C07H 21/04
US Classification:
435006000, 536024320
Abstract:
The present invention provides methods and compositions for identifying compounds useful as therapeutics and disinfectants. Such compounds would be particularly useful in treating Gram-positive bacterial infections. Such therapeutics would target the interaction of a tRNA molecule with an mRNA molecule, interrupting translation of the mRNA molecule and thus interfering with gene expression for a target gene critical to the survival of these organisms.

Compositions And Methods For The Identification Of Inhibitors Of Retroviral Infection

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US Patent:
20110033850, Feb 10, 2011
Filed:
Sep 12, 2008
Appl. No.:
12/678179
Inventors:
Paul F. Agris - Raleigh NC, US
Richard H. Guenther - Cary NC, US
International Classification:
C12Q 1/68
G01N 33/566
US Classification:
435 6, 436501
Abstract:
Methods of identifying inhibitors of retroviral propagation, tRNA used in the methods, and kits, including the tRNA, which can be used in the methods, are disclosed. Methods of treating or preventing retroviral infections by administering an effective amount of the inhibitors, and pharmaceutical compositions including the inhibitors, are also disclosed. The methods involve forming a mixture comprising a linear sequence of a tRNA anticodon stem loop fragment that is not capable of forming a stem-loop, a target nucleic acid molecule capable of binding to the tRNA anticodon stem loop fragment, and a test compound. The mixture is incubated under conditions that allow binding of the tRNA anticodon stem loop fragment and the target nucleic acid molecule in the absence of the test compound. Assays can then be performed that detect whether or not the test compound inhibits the binding of the tRNA anticodon stem loop fragment and the target nucleic acid molecule.

Isbn (Books And Publications)

Biomolecular Structure and Function

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Author

Paul F. Agris

ISBN #

0120439506

The Modified Nucleosides of Transfer RNA: A Bibliography of Biochemical and Biophysical Studies from 1970 to 1979

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Author

Paul F. Agris

ISBN #

0845102079

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Paul F Agris from Raleigh, NC, age ~79 Get Report