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Ralph Paul Volante

from Cranbury, NJ
Age ~74
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Also known as:
Ralph P Volante, Ellen S Volante, Ralph P Volant, Volante Rp, Ralph G
Phone and address:
7 Scottsdale Ct, East Windsor, NJ 08512
(609) 655-1406
Related to:
Joseph Daniel Ward, 52Melanie S Ward, 30Denise J Volante, 71Skip Volante, 74William F WardWilliam W Ward, 82Ellen S Ward, 69
Connected to:
Ashley G Volante, 43Jamie A Volante, 67Marco A Volante, 102Maurice A Volante, 45Michael A Volanti, 57Tracy L Volaric, 47Jody A Volat, 46Laura M Volcek, 66Frank D Volcensek, 49Vitaly Volchek, 62

Ralph Volante Phones & Addresses

  • 7 Scottsdale Ct, Cranbury, NJ 08512 (609) 655-1406 (609) 655-8293
  • 22 Hawthorne Ln, Hightstown, NJ 08520 (609) 655-8293
  • East Windsor, NJ
  • Metuchen, NJ
  • Brooklyn, NY
  • North Brunswick, NJ
  • Iselin, NJ

Publications

Us Patents

Process For The Synthesis Of Carbapenem Intermidiates, And Compounds Produced

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US Patent:
6395894, May 28, 2002
Filed:
Apr 15, 1999
Appl. No.:
09/292257
Inventors:
Philip J. Pye - Rahway NJ, 07065-0900
Paul J. Reider - Rahway NJ, 07065-0900
Kai Rossen - Rahway NJ, 07065-0900
Ralph P. Volante - Rahway NJ, 07065-0900
International Classification:
C07D47714
US Classification:
540200, 540302
Abstract:
A process of synthesizing a compound of structural formula 6 is disclosed wherein R represents H or a suitable protecting group for an alcohol; R represents a benzyl, C alkyl or aryl; Y represents C alkyl, O, NH or S; X represents O, NH, or S and R represents a carboxy protecting group, comprising reacting a compound of formula 5: wherein R , R , R , X and Y are as previously described with a phosphite or phosphonite reagent to produce a compound of formula 6. Further disclosed is an efficient method for the synthesis of a compound of formula 2: which comprises reacting a 4-acyl-2-azetidinone with a titanium, zirconium or hafnium enolate of a 1-hydroxy-2-butanone derivative.

Diastereoselective Preparation Of Michael Adducts

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US Patent:
6479672, Nov 12, 2002
Filed:
Apr 7, 2000
Appl. No.:
09/545313
Inventors:
Ioannis Houpis - Plainfield NJ
Ralph P. Volante - Cranbury NJ
Fengrui Lang - Piscataway NJ
Ilias Dorziotis - Bridgewater NJ
David Tschaen - Holmdel NJ
Shinji Kato - Nagoya NJ
Toshiaki Mase - Okazaki NJ
Assignee:
Merck Co., Inc. - Rahway NJ
Banyu Pharmaceutical Co., Ltd, - Tokyo
International Classification:
C07D31734
US Classification:
549267
Abstract:
Michael addition conducted in the presence of a zinc-amine complex and additional amounts of the amine component results in product with high diastereomeric excess.

Process For Making Spirolactone Compounds

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US Patent:
7368569, May 6, 2008
Filed:
Oct 14, 2003
Appl. No.:
10/531361
Inventors:
Ralph P. Volante - Cranbury NJ, US
David M. Tschaen - Holmdel NJ, US
Steven A. Weissman - Short Hills NJ, US
Matthew Heileman - New Providence NJ, US
Toshiaki Mase - Okazaki, JP
Takehiko Iida - Okazaki, JP
Kenji Maeda - Okazaki, JP
Toshihiro Wada - Tsukuba, JP
Hiroki Sato - Okazaki, JP
Kenichi Asakawa - Okazaki, JP
Assignee:
Merck & Co., Inc. - Rahway NJ
Banyu Pharmaceutical Co., Ltd. - Tokyo
International Classification:
C07D 405/12
C07D 405/14
C07D 307/94
C07D 491/107
US Classification:
544230, 544332, 544336, 544182, 546 15, 546167, 5483114, 5483644, 549265
Abstract:
This invention relates to a process for making spirolactone compounds analogous to formula I.

Process For Making Spirolactone Compounds

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US Patent:
7482449, Jan 27, 2009
Filed:
Mar 19, 2008
Appl. No.:
12/077419
Inventors:
Ralph P. Volante - Cranbury NJ, US
David M. Tschaen - Holmdel NJ, US
Steven A. Weissman - Short Hills NJ, US
Matthew Heileman - New Providence NJ, US
Toshiaki Mase - Okazaki, JP
Takehiko Iida - Okazaki, JP
Kenji Maeda - Okazaki, JP
Toshihiro Wada - Tsukuba, JP
Hiroki Sato - Okazaki, JP
Kenichi Asakawa - Okazaki, JP
Assignee:
Merck & Co., Inc. - Rahway NJ
Banyu Pharmaceutical Co., Ltd.
International Classification:
C07D 405/12
C07D 405/14
C07D 307/94
C07D 491/107
US Classification:
544230, 544231, 544182, 544332, 544336, 546 5, 546146, 5483114, 5483644, 549265
Abstract:
This invention relates to a process for making spirolactone compounds analogous to formula I.

Process For Making Spirolactone Compounds

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US Patent:
20060241299, Oct 26, 2006
Filed:
May 14, 2004
Appl. No.:
10/550136
Inventors:
Ralph Volante - Cranbury NJ, US
Steven Weissman - Short Hills NJ, US
Takehiko Iida - Okazaki, JP
Yuhei Yamamoto - Chicago IL, US
Hiroki Sato - Okazaki, JP
Kenji Maeda - Okazaki, JP
Naotaka Sawada - Okazaki, JP
Toshiaki Mase - Okazaki, JP
International Classification:
C07D 491/10
US Classification:
546016000
Abstract:
This invention relates to a process for making spirolactone compounds of general formula I, having an improved IA/IB ratio, according to the following shceme.

Convergent Process For The Preparation Of A Growth Hormone Secretagogue

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US Patent:
60463333, Apr 4, 2000
Filed:
Oct 21, 1997
Appl. No.:
8/955124
Inventors:
Ilias Dorziotis - Bridgewater NJ
Ioannis Houpis - Plainfield NJ
Audrey Molina - Clark NJ
Ralph Volante - Cranbury NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C07D40100
US Classification:
546 18
Abstract:
The present invention is directed to a novel convergent process for the preparation of the compound N-[1(R)-[(1,2-dihydro-1-methanesulfonyl-spiro[3H-indole-3,4'-piperdin]-1'- yl)carbonyl]-2-(phenylmethyl-oxy)ethyl]-2-amino-2-methyl-propanamide, and salts thereof, which has the structure: ##STR1## and which has the ability to stimulate the release of natural or endogenous growth hormone. This compound may be used to treat conditions which require the stimulation of growth hormone production or secretion such as in humans with a deficiency of natural growth hormone or in animals used for food or wool production where the stimulation of growth hormone will result in a larger, more productive animal.

Stereoselective Production Of Hydroxyamide Compounds From Chiral .Alpha.-Amino Epoxides

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US Patent:
51699524, Dec 8, 1992
Filed:
Jul 2, 1991
Appl. No.:
7/724617
Inventors:
David Askin - Warren NJ
Ralph Volante - East Windsor NJ
Michael Wallace - Matawan NJ
Ichiro Shinkai - Westfield NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C07C27120
C07D26352
C07D295104
US Classification:
544137
Abstract:
An efficient process for stereoselective preparation of a medicinally significant hydroxyamide compound of structural formula: ##STR1## comprises the addition of metalated amide enolates to chiral. alpha. -amino metalated epoxides. The hydroxyamide reaction products are useful as inhibitors of the HIV protease or of renin, or as intermediates in the preparation of inhibitors of the HIV protease or renin.

Process For Synthesis Of Arylglyoxal Arylimines

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US Patent:
48718734, Oct 3, 1989
Filed:
Mar 18, 1988
Appl. No.:
7/169649
Inventors:
Richard Desmond - Metuchen NJ
Sander G. Mills - Woodbridge NJ
Ralph P. Volante - East Windsor NJ
Ichiro Shinkai - Westfield NJ
Assignee:
Merck & Company Incorporated - Rahway NJ
International Classification:
C07C13100
US Classification:
564276
Abstract:
A process for producing arylglyoxal arylimine intermediates, by the DMSO/HBr oxidation of arylmethylketones. The imine compounds are intermediates in the synthesis of carbapenem antibiotics, i. e. imipenem.
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Ralph Paul Volante from Cranbury, NJ, age ~74 Get Report