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Ramamoorthy Belagaje Phones & Addresses

  • Carmel, IN
  • Indianapolis, IN
  • 10119 Summerlakes Dr, Carmel, IN 46032 (317) 292-1967

Work

Position: Service Occupations

Education

Degree: Bachelor's degree or higher

Publications

Us Patents

Derivative Of The Tryptophan Operon For Expression Of Fused Gene Products

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US Patent:
47389214, Apr 19, 1988
Filed:
Sep 27, 1984
Appl. No.:
6/655183
Inventors:
Ramamoorthy Belagaje - Indianapolis IN
Janet K. Epp - Indianapolis IN
JoAnn Hoskins - Indianapolis IN
Hansen M. Hsiung - Indianapolis IN
George L. Long - Indianapolis IN
Brigitte E. Schoner - Zionsville IN
Assignee:
Eli Lilly and Company - Indianapolis IN
International Classification:
C12P 2100
C12P 2102
C12N 1500
C12N 120
C12N 700
C07H 1512
US Classification:
435 68
Abstract:
The present invention comprises improved derivatives of the tryptophan operon useful for expressing fused gene products in E. coli and relate organism. Two of the improved derivatives disclosed are encoded on 0. 43 and 0. 55 kb EcoRI restriction fragments from plasmids pCZ20 and pLEBGH2 (in strains NRRL B-15881 and NRRL B-15882), respectively. The modified derivatives have been placed on recombinant DNA cloning and expression vectors. A variety of expression vectors have been constructed that drive expression of fused gene products. Two novel gene sequences, encoding insulin-like growth factors I and II, have been expressed with the modified tryptophan operon system.

Method For Using A Novel Transcriptional- And Translational-Activating Sequence In Streptomyces

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US Patent:
47525770, Jun 21, 1988
Filed:
Sep 13, 1984
Appl. No.:
6/650158
Inventors:
Ramamoorthy Belagaje - Indianapolis IN
Jeffrey T. Fayerman - Indianapolis IN
Mark A. Richardson - Indianapolis IN
Assignee:
Eli Lilly and Company - Indianapolis IN
International Classification:
C12N 1500
C12N 500
US Classification:
435 68
Abstract:
The present invention is a method for expressing functional polypeptides in Streptomyces using a recombinant DNA expression vector comprising a novel transcriptional- and translational- activating sequence. The novel activating sequence can be synthesized by conventional methods and used in Streptomyces expression vectors. One such vector, plasmid pFJ350, expresses and confers hygromycin resistance in Streptomyces host cells.

Transcription Terminators

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US Patent:
47104643, Dec 1, 1987
Filed:
Sep 27, 1984
Appl. No.:
6/655184
Inventors:
Ramamoorthy Belagaje - Indianapolis IN
Stuart A. Kuhstoss - Indianapolis IN
R. Nagaraja Rao - Indianapolis IN
Assignee:
Eli Lilly and Company - Indianapolis IN
International Classification:
C12P 1934
C12P 2100
C12N 1500
C12N 100
C12N 120
C12N 116
C12N 118
C07H 2104
US Classification:
435 91
Abstract:
The present transcription terminators are DNA sequences characterized by their ability to terminate the transcription of DNA sequences. The present sequences are portable, have a variety of restriction endonuclease sites and are useful in controlling the expression in hosts of DNA sequences coding for prokaryotic, eukaryotic and viral proteins and polypeptides.
Ramamoorthy M Belagaje from Carmel, IN, age ~82 Get Report