Richard A Bruce

6376481, Apr 23, 2002

Sep 2, 1998

09/145528

Richard D. Bruce - Rydal PA
John D. Higgins - Ft. Washington PA
Stephen A. Martellucci - Mont Clare PA

McNeil-PPC, Inc. - Skillman NJ

A61K 3156

514169, 424464, 424465, 424489, 514769, 514770, 514951, 514975

The present invention provides a sterol, stanol or their corresponding acid ester in a form suitable for the manufacture of an oral dosage form. A method for producing the oral dosage form is also provided.

6387411, May 14, 2002

Apr 4, 2001

09/826072

Richard D. Bruce - Rydal PA
Brid Burruano - King of Prussia PA
Michael R. Hoy - Sellersville PA
Nicholas R. Paquette - Danbury CT

McNeil-PPC, Inc. - Skillman NJ

A61K 914

424489, 424464, 424465, 5147723, 5147724, 514784, 514785, 514786, 514951

A method for preparing sterol/stanol and sterol/stanol ester compositions with improved dispersibility is provided by co-melting the sterol/stanol and/or sterol/stanol ester with highly branched hydrocarbons and then grinding the resulting product. A method for preparing the compounds is also disclosed. The ground compound is suitable for formulating into orally administered products suitable for control of blood serum cholesterol.

6399137, Jun 4, 2002

Jul 26, 2000

09/625667

Clemence K. Dartey - Itheca NY
Richard D. Bruce - Rydal PA
Brid T. Burruano - King of Prussia PA

McNeil-PPC, Inc. - Skillman NJ

A23D 9007

426602, 426611

The present invention provides a stable foodstuffs which contain a cholesterol lowering amount of a sterol or stanol ester, crystal fat inhibitors and emulsifiers. The foodstuffs, including salad dressings are stable even when refrigerated.

6654118, Nov 25, 2003

Jan 9, 2003

10/339584

Richard David Bruce - Rydal PA

Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ

G01J 344

356301, 356309, 356 73

This invention relates to a method and apparatus for the analysis of pharmaceutical specimens by nondestructively obtaining the molecular data for a chemical component on the surface or within the matrix of a pharmaceutical specimen.

54056179, Apr 11, 1995

Nov 7, 1991

7/790613

Walter G. Gowan - Glenside PA
Richard D. Bruce - Abington PA

McNeil-PPC, Inc. - Milltown NJ

A61K 916

424464

A physicochemically stable pharmaceutical matrix composition is provided comprising: a pharmaceutical active and a water insoluble aliphatic or fatty acid ester, preferably stearyl stearate; a taste mask carrier for pharmaceutical actives comprising a taste masking effective amount of an aliphatic or fatty acid ester; and a method for preparing a pharmaceutical matrix without the use of organic and/or volatile solvents comprising the steps of: melting an aliphatic or fatty acid ester; admixing at least one pharmaceutical active with the molten aliphatic or fatty acid ester; and solidifying the admixture to produce a pharmaceutical matrix composition. The matrix is composed of an aliphatic, or fatty acid, ester that has a low melting point (50. degree. -100. degree. C. ) and the melt exhibits: low viscosity, recongeals rapidly when cooled, does not exhibit polymorphism, and has good mold release properties.

6054144, Apr 25, 2000

Nov 4, 1998

9/185788

Brid Burruano - King of Prussia PA
Richard D. Bruce - Rydal PA
Michael R. Hoy - Sellersville PA
John D. Higgins - Ft. Washington PA

McNeil-PPC, Inc. - Skillman NJ

A61K 920

424464

A method for preparing. beta. -sitosterol, oryzanol, esters of both of these compounds and related compounds are disclosed which provides the sterol in a readily consumable form. The method includes the spray drying of the. beta. -sitosterol in a mixed micelle formulation. The product is provided in a convenient form that can be provided to food or drinks or incorporated into solid and suspension dosage forms.

61105023, Aug 29, 2000

Feb 19, 1998

9/025952

Brid Burruano - King of Prussia PA
Richard D. Bruce - Rydal PA
Michael R. Hoy - Sellersville PA

McNeil-PPC, Inc. - Skillman NJ

A61K 900
A61K 4700
A61K 920
A61K 914
A61K 950

424499

A method for preparing. beta. -sitosterol is disclosed which provides the sterol in a readily consumable form. The method includes the spray drying of the. beta. -sitosterol in a mixed micelle formulation. The product is provided in a convenient form that can be provided to food or drinks or incorporated into solid and suspension dosage forms.

62420011, Jun 5, 2001

Nov 30, 1998

9/200623

Richard D. Bruce - Rydal PA
Brid Burruano - King of Prussia PA
Michael R. Hoy - Sellersville PA
Nicholas R. Paquette - Danbury CT

McNeil-PPC, Inc.

A61K 914
A61K 920
A61K 31575

424464

A method for preparing sterol/stanol and sterol/stanol ester compositions with improved dispersibility is provided by co-melting the sterol/stanol and/or sterol/stanol ester with highly branched hydrocarbons and then grinding the resulting product. A method for preparing the compounds is also disclosed. The ground compound is suitable for formulating into orally administered products suitable for control of blood serum cholesterol.