Inventors:
Peter Bernstein - Wallingford PA
Robert Dedinas - Newark DE
Keith Russell - Newark DE
International Classification:
A61K 31445
US Classification:
514319, 514269, 514316, 514326, 544316, 546205, 546208, 546188
Abstract:
A compound of formula I wherein: R is alkyl; R is optionally substituted phenyl 2-oxo-tetrahydro-1(2H)-pyrimidinyl, or 2-oxo-1-piperidinyl; R is hydrogen, alkoxy, alkanoyloxy, alkoxycarbonyl, alkanoylamino, acyl, alkyl, carbamoyl, N-alkylcarbamoyl, N,N-dialkylcarbamoyl where the alkyl groups are the same or different, hydroxy, thioacyl, thiocarbamoyl, N-alkylthiocarbamoyl, or N,N-dialkylthiocarbamoyl where the alkyl groups are the same or different. X and X are independently hydrogen or halo, provided that at least one of X or X is halo; and R , R , R and R are independently hydrogen, cyano, nitro, trifluoromethoxy, trifluoromethyl, or alkylsulfonyl are antagonists of at least one tachykinin receptor and are useful in the treatment of depression, anxiety, asthma, pain, inflammation, urinary incontinence and other disease conditions. Process for their preparation are described, as are compositions containing them and their use.