Inventors:
Timothy Hla - Avon CT, US
Kevin Claffey - Burlington CT, US
Nicolas Ancellin - Farmington CT, US
Shobha Thangada - Glastonbury CT, US
International Classification:
A61K048/00
A61K031/366
Abstract:
Methods for the inhibition of angiogenesis are presented, comprising affecting the response of the EDG-1 receptor by the administration of pharmaceutically effective antagonists of EDG-1 signal transduction. This invention is based in part on the discovery that Akt protein kinase phosphorylation is required for endothelial cell chemotaxis mediated by the EDG-1 G protein-coupled receptor. This invention relates to the use of modifiers of EDG-1 signal transduction to treat disorders of undesired angiogenesis.