Sivakumar Munisamy

7544496, Jun 9, 2009

May 12, 2006

11/432941

Laurie B. Gower - Gainesville FL, US
Matthew J. Olszta - Gainesville FL, US
Elliot P. Douglas - Gainesville FL, US
Sivakumar Munisamy - Fords NJ, US
Donna L. Wheeler - Fort Collins CO, US

University of Florida Research Foundation, Inc. - Gainesville FL

C12N 11/00
C12N 11/14
C12N 11/02
C12N 11/10
C12N 11/12
C12N 11/08
C07K 17/04
C07K 17/10
C07K 17/12
C07K 17/08
A61K 9/00

435174, 435176, 435177, 435178, 435179, 435180, 435182, 530811, 530812, 530813, 530814, 530815, 530817, 424400, 424423, 424484

The subject invention concerns a composite comprising an organic fluid-swellable, fibrous matrix, such as collagen, and a mineral phase, such as calcium carbonate or phosphate mineral phase, for use as a biomimetic of bone. In another aspect, the subject invention concerns a process for making a composite involving the inclusion of acidic polymers to a supersaturated mineralizing solution, in order to induce an amorphous liquid-phase precursor to the inorganic mineral, which is then absorbed (pulled by capillary action) into the organic matrix. Advantageously, once solidified, a high mineral content can be achieved, with the inorganic mineral crystals embedded within the collagen fibers (intrafibrillarly) and oriented such that they are aligned along the long axes of the fibers of the organic matrix, thereby closely mimicking the natural structure of bone. The present invention further concerns a method of treating a patient suffering from a bone defect by applying a biomimetic composite to the bone defect site.

7547449, Jun 16, 2009

May 12, 2006

11/433725

Laurie B. Gower - Gainesville FL, US
Matthew J. Olszta - Gainesville FL, US
Elliot P. Douglas - Gainesville FL, US
Sivakumar Munisamy - Fords NJ, US
Donna L. Wheeler - Fort Collins CO, US

University of Florida Research Foundation, Inc. - Gainesville FL

A61F 2/00
A61K 9/00
C12N 5/00
C12N 11/00
C12N 11/14
C12N 11/02
C12N 11/10
C12N 11/12
C12N 11/08

424426, 424400, 424484, 424 937, 435174, 435176, 435177, 435178, 435179, 435180, 435182

The subject invention concerns a composite comprising an organic fluid-swellable, fibrous matrix, such as collagen, and a mineral phase, such as calcium carbonate or phosphate mineral phase, for use as a biomimetic of bone. In another aspect, the subject invention concerns a process for making a composite involving the inclusion of acidic polymers to a supersaturated mineralizing solution, in order to induce an amorphous liquid-phase precursor to the inorganic mineral, which is then absorbed (pulled by capillary action) into the organic matrix. Advantageously, once solidified, a high mineral content can be achieved, with the inorganic mineral crystals embedded within the collagen fibers (intrafibrillarly) and oriented such that they are aligned along the long axes of the fibers of the organic matrix, thereby closely mimicking the natural structure of bone. The present invention further concerns a method of treating a patient suffering from a bone defect by applying a biomimetic composite to the bone defect site.

20030232071, Dec 18, 2003

Apr 18, 2003

10/418843

Laurie Gower - Gainesville FL, US
Matthew Olszta - Gainesville FL, US
Elliot Douglas - Gainesville FL, US
Sivakumar Munisamy - Gainesville FL, US
Donna Wheeler - Fort Collins CO, US

A61K009/70
A61F013/00

424/443000

The subject invention concerns a composite comprising an organic fluid-swellable matrix, such as collagen, and mineral phase, such as calcium carbonate or phosphate mineral phase, for use as a biomimetic of bone. In another aspect, the subject invention concerns a process for making a composite involving the inclusion of acidic polymers to a supersaturated mineralizing solution, in order to induce an amorphous liquid-phase precursor to the inorganic mineral, which is then absorbed (pulled by capillary action) into the interstices of the organic matrix, and subsequently mineralizes via solidification and crystallization of the precursor phase. The present invention further concerns a method of treating a patient suffering from a bone defect by applying a biomimetic composite to the bone defect site.

20040131562, Jul 8, 2004

Oct 22, 2003

10/691002

Laurie Gower - Gainesville FL, US
Matthew Olszta - Gainesville FL, US
Elliot Douglas - Gainesville FL, US
Sivakumar Munisamy - Fords NJ, US
Donna Wheeler - Fort Collins CO, US

A61K007/16
A61C005/00

424/057000, 433/217100

The subject invention concerns a composite comprising an organic fluid-swellable, fibrous matrix, such as collagen, and a mineral phase, such as calcium carbonate or phosphate mineral phase, for use as a biomimetic of bone. In another aspect, the subject invention concerns a process for making a composite involving the inclusion of acidic polymers to a supersaturated mineralizing solution, in order to induce an amorphous liquid-phase precursor to the inorganic mineral, which is then absorbed (pulled by capillary action) into the organic matrix. Advantageously, once solidified, a high mineral content can be achieved, with the inorganic mineral crystals embedded within the collagen fibers (intrafibrillarly) and oriented such that they are aligned along the long axes of the fibers of the organic matrix, thereby closely mimicking the natural structure of bone. The present invention further concerns a method of treating a patient suffering from a bone defect by applying a biomimetic composite to the bone defect site.