Inventors:
Songping D. Huang - Kent OH, US
Soumitra Basu - Kent OH, US
Anatoly K. Khitrin - Kent OH, US
Eric Scott Soehnlen - Kent OH, US
Assignee:
Kent State University - Kent OH
International Classification:
A61B 5/055
A61K 51/00
A61K 49/00
US Classification:
424 936, 424 932, 424 111, 424 91
Abstract:
A material useful as a MRI contrast agent used for medical imaging, drug delivery platform or other functions are provided as a class of non-gadolinium and non-iron oxide based materials that comprise Prussian blue materials or analogue materials. The materials may be used as T-weighted and/or T-weighted MRI contrast agents for imaging, including cellular imaging, in clinical diagnosis and biomedical research applications. The agent is a compound created from Prussian blue materials that is non-toxic, and can be internalized by cells through endocytosis. The Prussian blue materials may also be used for drug delivery applications. The Prussian blue materials may be administered orally to a subject in either medical imaging or drug delivery applications or dual modality MRI-Fluorescence imaging agent.
