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Thomas C Tisone

from Irvine, CA
Age ~83
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Also known as:
Thomas Charles Tisone, Thomas C Tiscone, Tom Tisone, Lock Witmer, Witmer Lock
Related to:
Chris Tisone, 57John K Asaro, 72Josefina P Santamaria, 77Byron WitmerJennifer C Vaughan, 41Carol J Asaro, 64Key WitmerDaniel M Tisone, 54Christine A Witmer, 42Patricia A Tisone, 72
Connected to:
Lisa J Tisot, 58Belen Tissera, 44Kam TisseraGinger M Tissier, 44Alexandre G Tissot, 62Fred L Tissot, 95Tona L Tissue, 49Paul Tiszenkel, 71Nubea Tita, 34Phillip J Tita, 61

Thomas Tisone Phones & Addresses

  • Irvine, CA
  • Jackson, WY
  • 8407 Hillsdale Dr, Orange, CA 92869
  • Elroy, WI
  • Anaheim, CA

Work

Company: Cartesian technologies Jan 1996 to Aug 2002 Position: President

Education

Degree: Doctorates, Doctor of Philosophy School / High School: Northwestern University 1962 to 1967 Specialities: Physics

Skills

Biotechnology • Medical Devices • Commercialization • R&D • Hardware Diagnostics • Product Development • Validation • Lifesciences • Manufacturing • Product Marketing • Business Development • Automation • Point of Care Diagnostics

Industries

Biotechnology

Resumes

Resumes

Thomas Tisone Photo 1

President And Chief Executive Officer

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Location:
Irvine, CA
Industry:
Biotechnology
Work:
Cartesian Technologies Jan 1996 - Aug 2002
President
Biodot Jan 1996 - Aug 2002
President and Chief Executive Officer
Education:
Northwestern University 1962 - 1967
Doctorates, Doctor of Philosophy, Physics Colorado School of Mines 1958 - 1962
Bachelors, Bachelor of Science
Skills:
Biotechnology
Medical Devices
Commercialization
R&D
Hardware Diagnostics
Product Development
Validation
Lifesciences
Manufacturing
Product Marketing
Business Development
Automation
Point of Care Diagnostics

Business Records

Name / Title
Company / Classification
Phones & Addresses
Thomas C. Tisone
President, Vice President
BioDot, Inc
Medical Devices · Mfg Process Control Instruments Mfg Analytical Instruments · Instruments and Related Products Manufacturing for Measuring
2852 Alton Pkwy, Irvine, CA 92606
17781 Sky Park Cir, Irvine, CA 92614
(949) 440-3685
Thomas C. Tisone
Symbolics, LLC
Technology Developer & Licensor
4 Park Plz, Irvine, CA 92614
2852 Alton Pkwy, Irvine, CA 92606
Thomas C. Tisone
President
NOUVAS MANUFACTURING TECHNOLOGY COMPANY
17781 Cowan, Irvine, CA 92714

Publications

Us Patents

Tip Design And Random Access Array For Microfluidic Transfer

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US Patent:
6551557, Apr 22, 2003
Filed:
Dec 10, 1999
Appl. No.:
09/459245
Inventors:
Don Rose - Chapel Hill NC
Thomas C. Tisone - Orange CA
Assignee:
Cartesian Technologies, Inc. - Irvine CA
International Classification:
B01L 302
US Classification:
422100, 436180, 7386332, 7386331, 7386354, 73864, 7386401, 7386411, 7386424, 7386425, 7386431, 7386435
Abstract:
The present invention relates to a ceramic tip and a random access print head for the transfer of microfluidic quantities of fluid. The print head can randomly collect and deposit fluid samples to transfer the samples from a source plate to a target. The print head can also be programmed to create a direct map of the fluid samples from the source plate on the target or to create any desired pattern or print on the target. The tip and print head can be used for a wide variety of applications such as DNA microarraying and compound reformatting. In one preferred embodiment, the tip is used as a capillary or âgravityâ pin to draw or collect source fluid and âspotâ or deposit the fluid onto the target via physical contact (touch-off). In another preferred embodiment, the tip is used in conjunction with an aspirate-dispense system to actively aspirate source fluid and deposit the fluid via a contact or non-contact approach. The tip provides improved, accurate and repeatable microfluidic transfer.

Method For Dispensing Reagent Onto Substrate

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US Patent:
6576295, Jun 10, 2003
Filed:
Apr 5, 1999
Appl. No.:
09/286154
Inventors:
Thomas C. Tisone - Orange CA
Assignee:
Bio Dot, Inc. - Irvine CA
International Classification:
B05D 500
US Classification:
427256, 427421, 427424
Abstract:
A method and apparatus for dispensing precise quantities of reagents is disclosed including a positive displacement syringe pump in series with a dispenser, such as an aerosol dispenser or solenoid valve dispenser. The pump is controlled by a stepper motor or the like to provide an incremental quantity or continuous flow of reagent to the dispenser. The pump and dispenser are operated in cooperation with one another such that the quantity and/or flow rate of liquid dispensed by the dispenser can be precisely metered substantially independently of the particular operating parameters of said dispenser to attain a desired flow rate, droplet size or mist quality, droplet frequency and/or droplet velocity.

Dispensing Apparatus Having Improved Dynamic Range

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US Patent:
RE38281, Oct 21, 2003
Filed:
Jun 29, 2001
Appl. No.:
09/897788
Inventors:
Thomas C. Tisone - Orange CA
Assignee:
Biodot, Inc. - Irvine CA
International Classification:
G01N 3510
US Classification:
422100, 7386415, 7386424, 7386425, 118683, 118305, 239368, 239369, 239371, 422 81, 422103, 436 46, 436 54, 436180
Abstract:
A method and apparatus for dispensing precise quantities of reagents is disclosed including a positive displacement syringe pump in series with a dispenser, such as an aerosol dispenser or solenoid valve dispenser. The pump is controlled by a stepper motor or the like to provide an incremental quantity or continuous flow of reagent to the dispenser. The pump and dispenser are operated in cooperation with one another such that the quantity and/or flow rate of liquid dispensed by the dispenser can be precisely metered substantially independently of the particular operating parameters of said dispenser to attain a desired flow rate, droplet size or mist quality, droplet frequency and/or droplet velocity.

Methods And Systems For Dispensing Sub-Microfluidic Drops

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US Patent:
7470547, Dec 30, 2008
Filed:
Aug 2, 2004
Appl. No.:
10/909934
Inventors:
Thomas C. Tisone - Orange CA, US
Michelle Rodriquez - Mission Viejo CA, US
Michael K. Cabourne - Fullerton CA, US
Assignee:
Biodot, Inc. - Irvine CA
International Classification:
G01N 1/10
B01L 3/02
US Classification:
436180, 422100, 7386332, 73864, 2396901
Abstract:
The invention relates generally to dispensing of fluids and, in particular, to methods and systems for dispensing microfluidic or sub-microfluidic volumes of droplets of chemical, biological or other reagents or liquids. Embodiments of the invention have particular efficacy in accurately dispensing small drops having volumes from about 100 nL down into the picoliter range.

Method For Dispensing Reagent Onto A Substrate

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US Patent:
7541068, Jun 2, 2009
Filed:
Jun 6, 2006
Appl. No.:
11/447598
Inventors:
Thomas C. Tisone - Orange CA, US
Assignee:
BioDot, Inc. - Irvine CA
International Classification:
B05D 1/02
US Classification:
427483, 4274272, 427466
Abstract:
A method and apparatus for dispensing precise quantities of reagents is disclosed including a positive displacement syringe pump in series with a dispenser, such as an aerosol dispenser or solenoid valve dispenser. The pump is controlled by a stepper motor or the like to provide an incremental quantity or continuous flow of reagent to the dispenser. The pump and dispenser are operated in cooperation with one another such that the quantity and/or flow rate of liquid dispensed by the dispenser can be precisely metered substantially independently of the particular operating parameters of said dispenser to attain a desired flow rate, droplet size or mist quality, droplet frequency and/or droplet velocity.

Method And Apparatus For Liquid Dispensing

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US Patent:
7736591, Jun 15, 2010
Filed:
Apr 22, 2003
Appl. No.:
10/421636
Inventors:
Don Rose - Chapel Hill NC, US
Thomas C. Tisone - Orange CA, US
Assignee:
Biodot, Inc. - Irvine CA
International Classification:
B01L 3/02
US Classification:
422100, 7386332, 73864, 7386401, 7386402, 7386411
Abstract:
The present invention relates to a ceramic tip and a random access print head for the transfer of microfluidic quantities of fluid. The print head can randomly collect and deposit fluid samples to transfer the samples from a source plate to a target. The print head can also be programmed to create a direct map of the fluid samples from the source plate on the target or to create any desired pattern or print on the target. The tip and print head can be used for a wide variety of applications such as DNA microarraying and compound reformatting. In one preferred embodiment, the tip is used as a capillary or “gravity” pin to draw or collect source fluid and “spot” or deposit the fluid onto the target via physical contact (touch-off). In another preferred embodiment, the tip is used in conjunction with an aspirate-dispense system to actively aspirate source fluid and deposit the fluid via a contact or non-contact approach. The tip provides improved, accurate and repeatable microfluidic transfer.

Method And System For The Analysis Of High Density Cells Samples

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US Patent:
7754439, Jul 13, 2010
Filed:
Jun 10, 2004
Appl. No.:
10/866513
Inventors:
Mathew Moore - Irvine CA, US
Miriam Reyes - Irvine CA, US
David Baunoch - Irvine CA, US
Thomas Tisone - Irvine CA, US
Brendan O'Farrell - Irvine CA, US
Assignee:
Accupath Diagnostic Laboratories, Inc. - Irvine CA
Biodot, Inc. - Irvine CA
International Classification:
G01N 33/543
G01N 33/552
US Classification:
435 72, 435 721, 435 75, 4352871, 4352883, 4352884, 436527, 436530, 436531, 436809
Abstract:
Methods for forming cell arrays of multiple cell samples arranged substantially in a monolayer on a single substrate particularly suited for diagnostic analysis are disclosed. The cell arrays are formed with a high-speed dispensing apparatus capable of dispensing small volumes in precise, complex patterns. Also disclosed are substrates upon which cell arrays may be formed, and methods for conducting diagnostic analyses on the formed cell arrays.

Method And System For The Analysis Of High Density Cells Samples

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US Patent:
8323882, Dec 4, 2012
Filed:
Jul 9, 2010
Appl. No.:
12/833879
Inventors:
Mathew Moore - Irvine CA, US
Miriam Reyes - Irvine CA, US
David Baunoch - Irvine CA, US
Thomas Tisone - Irvine CA, US
Brendan O'Farrell - Irvine CA, US
Assignee:
Biodot, Inc. - Irvine CA
Accupath Diagnostic Laboratories, Inc. - Irvine CA
International Classification:
C12Q 1/00
US Classification:
435 4, 436518, 436524, 436527
Abstract:
Methods for forming cell arrays of multiple cell samples arranged substantially in a monolayer on a single substrate particularly suited for diagnostic analysis are disclosed. The cell arrays are formed with a high-speed dispensing apparatus capable of dispensing small volumes in precise, complex patterns. Also disclosed are substrates upon which cell arrays may be formed, and methods for conducting diagnostic analyses on the formed cell arrays.
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Thomas C Tisone from Irvine, CA, age ~83 Get Report