Inventors:
- Watertown MA, US
Torsten Herbertz - Stow MA, US
Goss S. Kauffman - Ledyard CT, US
Katherine J. Kayser-Bricker - Branford CT, US
George P. Luke - Clinton CT, US
Matthew W. Martin - Arlington MA, US
David S. Millan - Watertown MA, US
Shawn E.R. Schiller - Haverhill MA, US
Adam C. Talbot - Watertown MA, US
International Classification:
C07D 401/04
C07D 401/14
A61K 31/4709
A61K 45/06
A61K 31/47
A61K 31/497
A61K 31/506
A61K 31/5377
C07D 405/14
C07D 413/14
C07D 215/20
C07D 215/48
C07D 409/14
C07D 413/04
C07D 417/04
C07D 417/14
C07D 471/04
C07D 473/28
C07D 487/04
A61K 31/517
A61K 31/519
A61K 31/496
A61K 31/501
A61K 31/52
C07D 401/12
C07D 405/04
C07D 417/10
Abstract:
The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases, diabetes, and obesity, having Formula I:wherein W, X, Y, Z, R, R, R, and Rare as described herein.