Warren Kurtz - Lyndhurst NJ, US Stuart MacDonald - Pultneyville NY, US Howard Greenwald - Rochester NY, US
International Classification:
C12Q001/68 C12M001/34 C12N015/85 C12P021/06
US Classification:
435/006000, 435/287200, 435/455000, 435/069100
Abstract:
A process for stimulating the expression of a gene in which two different DNA constructs are disposed within a biological system and contacted with electromagnetic radiation, thereby causing each of the DNA constructs to express a gene product.
A quasistatic biological cell and tissue modifier is provided that presents a controlled electromagnetic environment which produces beneficial effects in biological material. The electromagnetic environment consists of a static magnetic field and a time-varying field. The static magnetic field potentiates the effect of the time-varying magnetic field and further modulates the amplitude at which the time-varying field is biologically active. The static field is provided by a permanent magnet or through electromagnetic means. In one embodiment the coil that produces the time-varying field is a single coplanar helical coil. In another embodiment it is a plurality of coplanar helical coil segments connected in parallel. In these two embodiments the coil is a flexible printed circuit that can be contoured around an organ. The static magnetic component is provided by a flexible permanent magnet or by the net bias of the time-varying field itself.
