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Zhaoyang M Wen

from San Francisco, CA
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Related to:
Chaohui Wen, 51Wen Jiajie, 29
Connected to:
Belinda C Wen, 35Candy WenJian X Wen, 67Jianzhong Wen, 42Joseph Wen, 37King L Wen, 59Stacy WenSusie WenTiffanie J Wen, 39Tiffany S Wen, 37

Zhaoyang Wen Phones & Addresses

  • San Francisco, CA

Work

Company: Genentech Oct 2002 to 2014 Position: Research associate

Education

Degree: Master of Science, Masters School / High School: University of San Francisco 1995 to 1998 Specialities: Organic Chemistry

Skills

Biotechnology • Cell Culture • Molecular Biology • Assay Development • Elisa • Purification • Lifesciences • Drug Discovery • Protein Purification • Pcr • Biochemistry • Gmp • Protein Chemistry • Western Blotting • Chromatography • Hplc • Sds Page • Biopharmaceuticals • Fda • Pharmaceutical Industry • Chemistry • Lc Ms • Drug Development • Organic Chemistry • Organic Synthesis • Research

Industries

Biotechnology

Resumes

Resumes

Zhaoyang Wen Photo 1

Zhaoyang Wen

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Location:
San Francisco, CA
Industry:
Biotechnology
Work:
Genentech Oct 2002 - 2014
Research Associate
Exelixis 2000 - 2002
Associate Scientist
Pfizer 1998 - 2000
Research Associate
Honeywell 1998 - 1998
Ra
Education:
University of San Francisco 1995 - 1998
Master of Science, Masters, Organic Chemistry Jinan University 1985 - 1990
Bachelors, Bachelor of Science, Chemistry
Skills:
Biotechnology
Cell Culture
Molecular Biology
Assay Development
Elisa
Purification
Lifesciences
Drug Discovery
Protein Purification
Pcr
Biochemistry
Gmp
Protein Chemistry
Western Blotting
Chromatography
Hplc
Sds Page
Biopharmaceuticals
Fda
Pharmaceutical Industry
Chemistry
Lc Ms
Drug Development
Organic Chemistry
Organic Synthesis
Research

Publications

Us Patents

Human Adam-10 Inhibitors

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US Patent:
7629341, Dec 8, 2009
Filed:
Jun 11, 2003
Appl. No.:
10/518110
Inventors:
Lynne Canne Bannen - Pacifica CA, US
Erick W. Co - Redwood City CA, US
Vasu Jammalamadaka - Pleasanton CA, US
John M. Nuss - Danville CA, US
Moon Hwan Kim - Palo Alto CA, US
Donna Tra Le - San Jose CA, US
Amy Lew - Milpitas CA, US
Zhaoyang Wen - San Francisco CA, US
Wei Xu - Danville CA, US
Assignee:
Symphony Evolution, Inc. - Rockville MD
International Classification:
C07D 213/10
C07D 401/06
C07D 401/12
C07D 241/04
A61K 31/495
A61K 31/496
A61K 31/5377
US Classification:
5142358, 51425211, 51425214, 51425302, 51425311, 544121, 544336, 544357
Abstract:
The present invention provides compounds useful for inhibiting the ADAM-10 protein, with selectivity versus MMP-1. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role.

Human Adam-10 Inhibitors

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US Patent:
7989661, Aug 2, 2011
Filed:
Oct 23, 2009
Appl. No.:
12/605118
Inventors:
Lynne Canne Bannen - Pacifica CA, US
Erick W. Co - Redwood City CA, US
Vasu Jammalamadaka - Pleasanton CA, US
John M. Nuss - Danville CA, US
Moon Hwan Kim - Palo Alto CA, US
Donna Tra Le - San Jose CA, US
Amy Lew - Milpitas CA, US
Morrison B. Mac - San Francisco CA, US
Zhaoyang Wen - San Francisco CA, US
Wei Xu - Danville CA, US
Richard George Khoury - Redwood City CA, US
Assignee:
Symphony Evolution, Inc. - Rockville MD
International Classification:
C07C 309/09
US Classification:
562828, 562830, 562833
Abstract:
The present invention provides compounds useful for inhibiting the ADAM-10 protein, with selectivity versus MMP-1. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role.

Kinase Modulators

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US Patent:
20060122171, Jun 8, 2006
Filed:
Nov 14, 2003
Appl. No.:
10/533555
Inventors:
Wei Xu - Danville CA, US
Lynne Canne Bannen - Pacifica CA, US
Samuel Brown - San Carlos CA, US
Erick Co - Redwood City CA, US
John Nuss - Danville CA, US
Moon Kim - Palo Alto CA, US
Rhett Klein - San francisco CA, US
Donna Lee - San Jose CA, US
Amy Tsuhako - Milpitas CA, US
Morrison Mac - San Francisco CA, US
Jason Parks - Sacramento CA, US
Zhaoyang Wen - San Francisco CA, US
Wei Cheng - San Jose CA, US
International Classification:
A61K 31/55
A61K 31/454
C07D 403/14
US Classification:
514217090, 514322000, 540603000, 546199000, 546201000
Abstract:
The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides oxindole derivatives which inhibit, regulate and/or modulate kinase receptor, particularly VEGF receptor 2 (Flk-1/KDR), FGFR1, and PDGFR (alpha and beta), signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.

Human Adam-10 Inhibitors

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US Patent:
20120071653, Mar 22, 2012
Filed:
Jun 23, 2011
Appl. No.:
13/167128
Inventors:
Lynne Canne Bannen - Pacifica CA, US
Erick W. Co - Redwood City CA, US
Vasu Jammalamadaka - Pleasanton CA, US
John M. Nuss - Danville CA, US
Moon Hwan Kim - Palo Alto CA, US
Donna Tra Le - San Jose CA, US
Amy Lew - Milpitas CA, US
Morrison B. Mac - San Francisco CA, US
Zhaoyang Wen - San Francisco CA, US
Wei Xu - Danville CA, US
Richard George Khoury - Redwood City CA, US
Assignee:
SYMPHONY EVOLUTION, INC. - Rockville MD
International Classification:
C07D 241/04
C07D 413/06
US Classification:
544121, 544383
Abstract:
The present invention provides compounds useful for inhibiting the ADAM-10 protein, with selectivity versus MMP-1. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role.

Raf Inhibitor Compounds And Methods Of Use Thereof

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US Patent:
20120157439, Jun 21, 2012
Filed:
Aug 27, 2010
Appl. No.:
13/393163
Inventors:
Ignacio Aliagas - South San Francisco CA, US
Stefan Gradl - South San Francisco CA, US
Janet Gunzner - South San Francisco CA, US
Simon Mathieu - South San Francisco CA, US
Rebecca Pulk - South San Francisco CA, US
Joachim Rudolph - South San Francisco CA, US
Zhaoyang Wen - South San Francisco CA, US
Jonas Grina - Boulder CO, US
Joshua D. Hansen - Boulder CO, US
Ellen Laird - Boulder CO, US
David Moreno - Boulder CO, US
Li Ren - Boulder CO, US
Steven Mark Wenglowsky - Boulder CO, US
Assignee:
GENENTECH, INC. - South San Francisco CA
ARRAY BIOPHARMA INC. - Boulder CO
International Classification:
A61K 31/519
C07D 495/04
A61P 35/00
A61K 31/5377
A61K 31/53
C07D 487/04
C07D 513/04
US Classification:
51421021, 544280, 544278, 544255, 544117, 544183, 5142651, 5142601, 5142342, 514243
Abstract:
Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Raf Inhibitor Compounds And Methods Of Use Thereof

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US Patent:
20120157453, Jun 21, 2012
Filed:
Aug 27, 2010
Appl. No.:
13/393111
Inventors:
Ignacio Aliagas - South San Francisco CA, US
Stefan Gradl - South San Francisco CA, US
Janet Gunzner - South San Francisco CA, US
Simon Mathieu - South San Francisco CA, US
Joachim Rudolph - South San Francisco CA, US
Zhaoyang Wen - South San Francisco CA, US
Steven Mark Wenglowsky - Boulder CO, US
Assignee:
GENENTECH, INC. - South San Francisco CA
ARRAY BIOPHARMA INC. - Boulder CO
International Classification:
A61K 31/519
A61K 31/52
C07D 487/04
C07D 495/04
C07D 491/048
A61P 13/12
A61P 35/00
A61P 25/28
A61P 9/00
A61P 29/00
A61P 25/06
A61P 25/00
C07D 473/34
A61K 31/5377
US Classification:
5142342, 544277, 5142634, 544262, 5142621, 544280, 5142651, 544254, 5142611, 544278, 5142601, 544250, 514267, 51426337, 544118
Abstract:
Compounds of Formula II are useful for inhibition of Raf kinases. Methods of using compounds of Formula II and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Raf Inhibitor Compounds And Methods Of Use Thereof

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US Patent:
20120214811, Aug 23, 2012
Filed:
Aug 27, 2010
Appl. No.:
13/393138
Inventors:
Ignacio Aliagas - South San Francisco CA, US
Stefan Gradl - South San Francisco CA, US
Janet Gunzner - South San Francisco CA, US
Simon Mathieu - South San Francisco CA, US
Rebecca Pulk - South San Francisco CA, US
Joachim Rudolph - South San Francisco CA, US
Zhaoyang Wen - South San Francisco CA, US
International Classification:
A61K 31/5377
A61K 31/505
A61P 35/00
C07D 403/12
C07D 251/42
A61K 31/53
C07D 239/48
C07D 413/12
US Classification:
5142358, 544329, 514256, 544122, 544328, 544211, 514245
Abstract:
Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Raf Inhibitor Compounds And Methods Of Use Thereof

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US Patent:
20130018033, Jan 17, 2013
Filed:
Aug 27, 2010
Appl. No.:
13/393116
Inventors:
Ignacio Aliagas - South San Francisco CA, US
Stefan Gradl - South San Francisco CA, US
Janet Gunzner - South San Francisco CA, US
Wendy Lee - South San Francisco CA, US
Simon Mathieu - South San Francisco CA, US
Joachim Rudolph - South San Francisco CA, US
Zhaoyang Wen - South San Francisco CA, US
Guiling Zhao - South San Francisco CA, US
Alexandre J. Buckmelter - Boulder CO, US
Jonas Grina - Boulder CO, US
Joshua D. Hansen - Boulder CO, US
Ellen Laird - Boulder CO, US
David Moreno - Boulder CO, US
Li Ren - Boulder CO, US
Steven Mark Wenglowsky - Boulder CO, US
Assignee:
ARRAY BIOPHARMA INC. - Boulder CO
International Classification:
A61K 31/517
C07D 471/04
A61K 31/519
C07D 405/12
A61P 35/02
C07D 401/12
C07D 413/12
A61K 31/5377
C07D 239/72
A61P 35/00
C07D 239/94
C07D 403/12
US Classification:
51421021, 544293, 5142664, 544279, 51426411, 544119, 5142345, 544284, 544283, 5142661
Abstract:
Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
Control profile
Zhaoyang M Wen from San Francisco, CA Get Report