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Jerome F Mahiou

from Lexington, MA
Age ~57

Jerome Mahiou Phones & Addresses

  • 62 Gleason Rd, Lexington, MA 02420 (781) 862-2066
  • 1466 Tremont St, Roxbury Crossing, MA 02120 (617) 442-7233

Work

Company: Escoublac inc 2010 Position: Vp of research

Education

School / High School: University R. Descartes 1998 Specialities: Ph.D. in Immunology

Resumes

Resumes

Jerome Mahiou Photo 1

Senior Scientist And Group Leader - Molecular Biology And Gene Editing

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Location:
Lexington, MA
Industry:
Biotechnology
Work:
Escoublac - Cambridge, MA (Biogen Idec Innovations Incubator) Jan 2010 - Jan 2011
Director of Research

Epix Pharmaceuticals - Lexington, MA Jan 2008 - Apr 2009
Senior scientist

Synta Pharmaceuticals Apr 2001 - Dec 2007
Senior Scientist
Education:
Université René Descartes (Paris V) 1992 - 1998
PhD, Immunology
Skills:
Immunology
Molecular Biology
Biotechnology
Cell Biology
In Vivo
Pharmaceuticals
Cell Based Assays
R&D
Proof of Concept/Validation
Recombinant Protein
Protein Chemistry
Pharmaceutical Industry
Cell
Drug Discovery
Drug Development
Animal Models
Medicinal Chemistry
In Vitro
Elisa
Biochemistry
Clinical Development
High Throughput Screening
Cancer
Assay Development
Neuroscience
Cro
Inflammation
Biopharmaceuticals
Laboratory
Biomarkers
Validation
Cell Signaling
Lifesciences
Pharmacology
Jerome Mahiou Photo 2

Senior Scientist

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Location:
Boston, MA
Industry:
Pharmaceuticals
Work:
Synta Pharmaceuticals
Senior Scientist
Education:
Université Paris Descartes 1992 - 1998
Jerome Mahiou Photo 3

Jerome Mahiou Lexington, MA

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Work:
ESCOUBLAC INC

2010 to Present
VP OF RESEARCH

EPIX PHARMACEUTICALS
Lexington, MA
2008 to 2009
SENIOR SCIENTIST

SYNTA PHARMACEUTICALS

2005 to 2008
SENIOR SCIENTIST

SYNTA PHARMACEUTICALS
Lexington, MA
2002 to 2008

SYNTA PHARMACEUTICALS

2002 to 2005
SCIENTIST II

DEPARTMENT OF SURGERY, Harvard University, BIDMC
Boston, MA
1998 to 2002
POSTDOCTORAL FELLOW

DEPARTMENT OF IMMUNO-PHARMACOLOGY

1992 to 1998
Ph.D. STUDENT

DEPARTMENT OF IMMUNO-PHARMACOLOGY
Paris (75)
1991 to 1998

DEPARTMENT OF IMMUNO-PHARMACOLOGY

1991 to 1992
RESEARCH ASSOCIATE

Education:
University R. Descartes
1998
Ph.D. in Immunology

University P. & M. Curie
1991
B.S. in Cellular Biology

Implication of the FAS receptor and its ligand in autoimmunity

Publications

Us Patents

Compounds For Inflammation And Immune-Related Uses

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US Patent:
8314134, Nov 20, 2012
Filed:
Mar 5, 2010
Appl. No.:
12/718366
Inventors:
Shoujun Chen - Bedford MA, US
Jun Jiang - Acton MA, US
Hao Li - Brookline MA, US
David James - Cambridge MA, US
Dinesh Chimmanamada - Waltham MA, US
Christopher Borella - Cambridge MA, US
Lijun Sun - Harvard MA, US
Yu Xie - Natick MA, US
Mats Holmqvist - Malden MA, US
Jerome Mahiou - Lexington MA, US
Zhiqiang Xia - Acton MA, US
Assignee:
Synta Pharmaceuticals Corp. - Lexington MA
International Classification:
C07D 235/00
A01N 43/52
A61K 31/415
US Classification:
514393, 514394, 5483044, 5483107
Abstract:
The invention relates to compounds of formula (I):.

Compounds For Inflammation And Immune-Related Uses

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US Patent:
8524756, Sep 3, 2013
Filed:
Oct 16, 2012
Appl. No.:
13/652878
Inventors:
Jun Jiang - Norwood MA, US
Hao Li - Brookline MA, US
David A. James - Cambridge MA, US
Dinesh Chimmanamada - Waltham MA, US
Christopher Borella - Cambridge MA, US
Lijun Sun - Harvard MA, US
Yu Xie - Natick MA, US
Mats Holmqvist - Malden MA, US
Jerome Mahiou - Lexington MA, US
Zhiqiang Xia - Acton MA, US
Assignee:
Synta Pharmaceuticals Corp. - Lexington MA
International Classification:
A01N 43/52
A61K 31/415
US Classification:
514393
Abstract:
The invention relates to compounds of formula (I):.

Novel Calcium Channels And Uses Thereof

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US Patent:
20050074850, Apr 7, 2005
Filed:
May 28, 2004
Appl. No.:
10/856122
Inventors:
Monica Nadler - Framingham MA, US
Jean-Pierre Kinet - Lexington MA, US
Pierre Launay - Brighton MA, US
Jerome Mahiou - Lexington MA, US
Assignee:
Synta Pharmaceuticals Corp. - Lexington MA
Beth Israel Deaconess Medical Center, Inc. - Boston MA
International Classification:
C07K014/705
C07H021/04
US Classification:
435069100, 435320100, 435325000, 530350000, 536023500
Abstract:
Differentially expressed L-type calcium channel nucleic acid sequences and polypeptides have been identified that include novel sequences that are differentially expressed in non-excitable cells. Such sequences can be used, for example, as targets for identifying agents that modulate calcium influx, e.g., in non-excitable cells. Methods related to modulation of cell growth are also included.

Compounds For Inflammation And Immune-Related Uses

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US Patent:
20050107436, May 19, 2005
Filed:
Jul 22, 2004
Appl. No.:
10/897681
Inventors:
Yu Xie - Natick MA, US
Mats Holmqvist - Malden MA, US
Jerome Mahiou - Lexington MA, US
Mitsunori Ono - Lexington MA, US
Lijun Sun - Harvard MA, US
Shoujun Chen - Bedford MA, US
Shijie Zhang - Nashua NH, US
Jun Jiang - Acton MA, US
Dinesh Chimmanamada - Waltham MA, US
Chih-Yi Yu - Malden MA, US
International Classification:
A61K031/444
A61K031/4439
A61K031/4196
US Classification:
514332000, 514341000, 514383000, 514438000, 514461000, 514408000
Abstract:
The invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof wherein X, Y, A, Z, L and n are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions and immune disorders.

Method For Modulating Calcium Ion-Release-Activated Calcium Ion Channels

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US Patent:
20050148633, Jul 7, 2005
Filed:
Jul 22, 2004
Appl. No.:
10/897682
Inventors:
Yu Xie - Natick MA, US
Mats Holmqvist - Malden MA, US
Jerome Mahiou - Lexington MA, US
Mitsunori Ono - Lexington MA, US
Lijun Sun - Harvard MA, US
Shoujun Chen - Bedford MA, US
Shijie Zhang - Nashua NH, US
Jun Jiang - Acton MA, US
Dinesh Chimmanamada - Waltham MA, US
Andrea Fleig - Honolulu HI, US
Chih-Yi Yu - Malden MA, US
International Classification:
A61K031/724
A61K031/444
A61K031/4439
A61K031/4196
A61K031/381
A61K031/35
US Classification:
514332000, 514340000, 514422000, 514058000, 514383000, 514397000, 514451000, 514438000
Abstract:
The invention relates to a method for modulating Ca-release-activated Ca channels (CRAC) in a cell by administering to the cell a compound of formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof wherein X, Y, A, Z, L and n are defined herein.

Compounds For Inflammation And Immune-Related Uses

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US Patent:
20070249661, Oct 25, 2007
Filed:
Sep 21, 2005
Appl. No.:
11/233224
Inventors:
Shoujun Chen - Bedford MA, US
Jun Jiang - Acton MA, US
Hao Li - Brookline MA, US
David James - Cambridge MA, US
Dinesh Chimmanamada - Waltham MA, US
Christopher Borella - Cambridge MA, US
Lijun Sun - Harvard MA, US
Yu Xie - Natick MA, US
Mats Holmqvist - Malden MA, US
Jerome Mahiou - Lexington MA, US
Zhi Xia - Acton MA, US
Assignee:
Synta Pharmaceuticals Corp. - Lexington MA
International Classification:
A61K 31/44
A61K 31/40
A61K 31/415
A61P 19/02
A61P 5/00
C07D 235/28
C07D 471/02
C07D 455/02
C07D 235/00
A61P 3/10
A61P 17/00
A61K 31/437
US Classification:
514303000, 514299000, 514393000, 514394000, 514395000, 546118000, 546121000, 548304400, 548307100
Abstract:
The invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof wherein X, Y, A, Z, L and n are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions and immune disorders.

Compounds For Inflammation And Immune-Related Uses

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US Patent:
20150005320, Jan 1, 2015
Filed:
Sep 27, 2013
Appl. No.:
14/040310
Inventors:
- Lexington MA, US
Mats Holmqvist - Malden MA, US
Jerome Mahiou - Lexington MA, US
Mitsunori Ono - Lexington MA, US
Lijun Sun - Harvard MA, US
Shoujun Chen - Bedford MA, US
Shijie Zhang - Nashua NH, US
Jun Jiang - Westwood MA, US
Dinesh Chimmanamada - Waltham MA, US
Chih-Yi Yu - Malden MA, US
Assignee:
Synta Pharmaceuticals Corp. - Lexington MA
International Classification:
C07C 233/66
C07C 237/42
C07D 333/38
C07D 239/28
C07D 263/34
C07D 231/14
C07D 285/06
C07D 213/81
C07D 277/56
US Classification:
514256, 546323, 514354, 564184, 514617, 564155, 514616, 549 72, 514448, 548200, 514365, 548236, 514374, 5483741, 514406, 548127, 514361, 544335
Abstract:
The invention relates to compounds of formula (I):or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof wherein X, Y, A, Z, L and n are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions and immune disorders.
Jerome F Mahiou from Lexington, MA, age ~57 Get Report